SHA 68
中文名称 | SHA 68 |
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中文同义词 | N-(4-氟苄基)-3-氧代-1,1-二苯基四氢-1H-恶唑并[3,4-A]吡嗪-7(3H)-羧酰胺;化合物SHA 68;SHA 68,神经肽S受体拮抗剂;N-(4-氟苄基)-3-氧代-1,1-二苯基四氢-3H-恶唑并[3,4-A]吡嗪-7(1H)-甲酰胺 |
英文名称 | SHA 68 |
英文同义词 | SHA 68;N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide;N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-;N-(4-Fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide |
CAS号 | 847553-89-3 |
分子式 | C26H24FN3O3 |
分子量 | 445.49 |
EINECS号 | |
相关类别 | |
Mol文件 | 847553-89-3.mol |
结构式 |
SHA 68 性质
沸点 | 727.8±60.0 °C(Predicted) |
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密度 | 1.35±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMF:16 mg/ml; DMSO:14 mg/ml;乙醇:20 mg/ml;乙醇:PBS (pH 7.2)(1:2): 0.33 mg/ml |
形态 | 结晶固体 |
酸度系数(pKa) | 13.32±0.40(Predicted) |
颜色 | 白色至米白色 |
SHA 68 是一种有效的选择性非肽神经肽 S 受体 (NPSR) 拮抗剂,对 NPSR Asn107 和 NPSR Ile107 的 IC50 分别为 22.0 和 23.8 nM。SHA 68 具有有限的血脑屏障 (BBB) 渗透能力和用于神经痛的活性。
IC50: 22 nM (Asn 107 ) and 23.8 nM (Ile 107 )
SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing.
SHA 68 (i.v.; 1 mg/kg) has a T
1/2
of 0.74 hours, a CL of 4.29 mL/min/kg, and a V
ss
of 2.53 L/kg.
SHA 68 (i.p.; 2.5 mg/kg) has a T
1/2
of 0.43 hours, a CL of 4.56 mL/min/kg.
Animal Model: | Male C57BL/6 mice age 8-12 weeks |
Dosage: | 5 and 50 mg/kg |
Administration: | i.p. |
Result: | Reduced NPS-induced horizontal activity and vertical rearing and climbing. |
Animal Model: | Male C57BL/6 mice age 8-12 weeks |
Dosage: | 1 mg/kg (Pharmacokinetic Analysis) |
Administration: | i.p. |
Result: | Had a T 1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a V ss of 2.53 L/kg. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-108625 | SHA 68 | 5 mg | 825元 | |
2024/08/19 | HY-108625 | SHA 68 SHA 68 | 847553-89-3 | 10mM * 1mLin DMSO | 907元 |