羟基安非他酮
中文名称 | 羟基安非他酮 |
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中文同义词 | 羟基安非他酮;1-(3-氯苯基)-2-[(1-羟基-2-甲基丙-2-基)氨基]丙-1-酮;安非他酮杂质7;安非他酮羟基杂质;(±)-羟基丁氨苯丙酮;安非他酮杂质24;(±)-羟基安非他酮 溶液 |
英文名称 | Hydroxybupropione |
英文同义词 | HYDROXYBUPROPION;HYDROXYBUPROPIONE;1-(3-CHLOROOPHENYL)-2-[(2-HYDROXY-1,1-DIMETHYLETHYL)AMINO]-1-PROPANONE;2-HYDROXY-2-(3'-CHLOROPHENYL)-3,5,5-TRIMETHYLMORPHOLINE;1-(3-Chloroophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1-propanone,2-Hydroxy-2-(3chlorophenyl)-3,5,5-trimethylmorpholine;1-(3-Chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one;1-(3-Chlorophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1-propanone;(±)-Hydroxybupropion solution |
CAS号 | 92264-81-8 |
分子式 | C13H18ClNO2 |
分子量 | 255.74 |
EINECS号 | 200-835-2 |
相关类别 | 化工原料;临床检测标准物质;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Bupropion |
Mol文件 | 92264-81-8.mol |
结构式 |
羟基安非他酮 性质
熔点 | 121-123°C |
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沸点 | 393.9±32.0 °C(Predicted) |
密度 | 1.150±0.06 g/cm3(Predicted) |
闪点 | 2℃ |
储存条件 | -20°C |
溶解度 | 乙腈(微溶)、氯仿(微溶)、DMSO(微溶)、甲醇(微溶) |
形态 | 固体 |
酸度系数(pKa) | 15.43±0.10(Predicted) |
颜色 | 白色至浅黄色 |
IC50: 1.7 μM (Norepinephrine uptake)
nACh receptor
Plasma levels of Hydroxybupropion greatly exceed those of the parent drug, reaching 10 to 100 times the concentration of Bupropion. Hydroxybupropion shows stronger antitetrabenazine activity (indicative of an antidepressant activity in animals) and has a lower LD50 value than the erythro- and threo- metabolites, suggesting that Hydroxybupropion is the most important active metabolite in vivo for its antidepressant activity. Hydroxybupropion is pharmacologically active, inhibiting norepinephrine and dopamine uptake, and antagonizing nicotine and showing antidepressant effects in rodents.
安全信息
危险品标志 | F,Xn |
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危险类别码 | 11-20/21/22-36 |
安全说明 | 16-36/37 |
危险品运输编号 | UN 1648 3 / PGII |
WGK Germany | 2 |
海关编码 | 3822900000 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-100637 | 羟基安非他酮 Hydroxybupropion | 92264-81-8 | 5mg | 2500元 |
2024/01/25 | HY-100637 | 羟基安非他酮 Hydroxybupropion | 92264-81-8 | 10mM * 1mLin DMSO | 2750元 |