槐角苷
| 中文名称 | 槐角苷 |
|---|---|
| 中文同义词 | 槐角苷;槐属甙;染料木素-4-葡萄糖甙;槐角甙;槐苷;槐属苷(标准品);SOPHORICOSIDE 槐角苷;槐黄苷,染料木素-4'-葡萄糖苷 |
| 英文名称 | Sophoricoside |
| 英文同义词 | SOPHORICOSIDE;ISOGENISTIN;GENISTEIN-4'-GLUCOSIDE;GENISTEIN-4'-O-GLUCOSIDE;4H-1-Benzopyran-4-one,3-[4-(β-;D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-;Sophoricoside ,98%;3-[4-(β-D-Glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one |
| CAS号 | 152-95-4 |
| 分子式 | C21H20O10 |
| 分子量 | 432.38 |
| EINECS号 | |
| 植物来源 | 槐米 |
| 相关类别 | 中药对照品;标准品;对照品,标准品;分析标准品;植物提取物;对照品;植提标准品;中药标准品;Miscellaneous Natural Products;Natural Plant Extract;分析试剂标准品;原料;对照品-中药对照品;黄酮;标准品 -中药标准品;分析试剂-标准品;标准品，对照品;黄金产品;生化试剂 |
| Mol文件 | 152-95-4.mol |
| 结构式 |  |
槐角苷 性质
| 熔点 | 298° |
|---|---|
| 比旋光度 | D20 -47° (pyridine); D20 -32° (10% aq pyridine) |
| 沸点 | 466.08°C (rough estimate) |
| 密度 | 1.3597 (rough estimate) |
| 折射率 | 1.5376 (estimate) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 可溶于水基（轻微）、DMSO（轻微、加热）、吡啶（轻微、超声处理） |
| 酸度系数(pKa) | 6.45±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
| 最大波长(λmax) | 271nm(MeOH)(lit.) |
| CAS 数据库 | 152-95-4(CAS DataBase Reference) |
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner.
When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| 海关编码 | 29329990 |