4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine manufacturers
- CRAC intermediate 2
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- $73.00 / 100mg
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2026-04-22
- CAS:123066-64-8
- Min. Order:
- Purity: 99.69%
- Supply Ability: 10g
- CRAC intermediate 2
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- $73.00 / 100mg
-
2026-04-20
- CAS:123066-64-8
- Min. Order:
- Purity: 99.69%
- Supply Ability: 10g
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| | 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Basic information |
| Product Name: | 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine | | Synonyms: | 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine;4-(3,5-Bis(trifluoroMethyl)-1H-pyrazol-1-yl)aniline;CRAC intermediate 2;4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline;CRAC 2;Benzenamine, 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-;CRAC intermediate-2,Ca2+ release-activated Ca2+ channels,CRAC intermediate2,Inhibitor,CRAC Channel,CRAC intermediate 2,inhibit,Calcium release-activated channels;CRAC intermediate 2, 10 mM in DMSO | | CAS: | 123066-64-8 | | MF: | C11H7F6N3 | | MW: | 295.18 | | EINECS: | | | Product Categories: | | | Mol File: | 123066-64-8.mol |  |
| | 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Chemical Properties |
| Melting point | 140-142 °C | | Boiling point | 298.4±40.0 °C(Predicted) | | density | 1.52±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO : ≥ 52 mg/mL (176.16 mM) | | form | Solid | | pka | 2.65±0.10(Predicted) | | color | Light yellow to yellow |
| | 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Usage And Synthesis |
| Uses | CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1. | | Synthesis | Under hydrogen atmosphere, 1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (4.4 g, 13.5 mmol) was dissolved in EtOAc (44 mL) and Pd/C (1.3 g) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was vacuum filtered through a diatomaceous earth pad and the filter cake was washed with EtOAc. The filtrate was concentrated under reduced pressure to afford 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-aniline (compound 13) as a light yellow solid (3.75 g, 12.7 mmol, 94% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3) and mass spectrometry (MS): 1H-NMR δ 7.22 (d, J=8.5 Hz, 2H), 7.00 (s, 1H), 6.72 (d, J=8.5 Hz, 2H); MS m/z: [M+H]+ 296. | | References | [1] Journal of Organic Chemistry, 2011, vol. 76, # 16, p. 6657 - 6669
[2] Patent: WO2017/212414, 2017, A1. Location in patent: Page/Page column 43
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 2975 - 2981 |
| | 4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-phenylamine Preparation Products And Raw materials |
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