2-Chloro-5-methoxypyrimidine

2-Chloro-5-methoxypyrimidine Suppliers list

Company Name:	Liyang Kunlu biological technology co.,ltd Gold
Tel:	0519-87310015 13813530041
Email:	200601296@qq.com

Company Name:	Shandong RuiYue Biotechnology Co., Ltd. Gold
Tel:	0531-88581623 18805314509
Email:	1456922171@126.com

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

Company Name:	BeiJing Hwrk Chemicals Limted
Tel:	0757-86329057 18934348241
Email:	sales4.gd@hwrkchemical.com

2-Chloro-5-methoxypyrimidine manufacturers

2-Chloro-5-methoxypyrimidine Basic information

Product Name:	2-Chloro-5-methoxypyrimidine
Synonyms:	Pyrimidine, 2-chloro-5-methoxy- (8CI,9CI);2-Chloro-5-methoxypyrimidine;PyriMidine,2-chloro-5-Methoxy-;2-Chloro-5-MethoxypyriMidine 97%;2-Chloro-5-methoxypyrimidine >;2-Chloro-5-methoxypyrimidine ISO 9001：2015 REACH;2-Chloro-5-methoxypyrimidine, 97%,;2-CHLORO-5-(METHOXY-D3)PYRIMIDINE
CAS:	22536-65-8
MF:	C5H5ClN2O
MW:	144.56
EINECS:	636-584-4
Product Categories:	Heterocycle-Pyrimidine series;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;PYRIMIDINE;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks
Mol File:	22536-65-8.mol

2-Chloro-5-methoxypyrimidine Chemical Properties

Melting point	73-78℃
Boiling point	268.8±13.0 °C(Predicted)
density	1.292±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	-1.26±0.22(Predicted)
color	White to Almost white
InChI	InChI=1S/C5H5ClN2O/c1-9-4-2-7-5(6)8-3-4/h2-3H,1H3
InChIKey	RSUBGBZOMBTDTI-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(OC)C=N1
CAS DataBase Reference	22536-65-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	37/38-41
Safety Statements	26-39
WGK Germany	3
HS Code	29335990
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3

MSDS Information

2-Chloro-5-methoxypyrimidine Usage And Synthesis

Chemical Properties	off-white powder
Uses	2-Chloro-5-methoxypyrimidine is used in the regioselective synthesis of aminoimidazopyrimidines with triflic anhydride and pyridine bases
Synthesis	19646-07-2 22536-65-8 General procedure for the synthesis of 2-chloro-5-methoxypyrimidine from 2,4-dichloro-5-methoxypyrimidine: 1. 2,4-Dichloro-5-methoxypyrimidine (43 g, 0.24 mol), zinc powder (86 g, 1.32 mol), ethanol (200 mL), and water (200 mL) were mixed, heated to reflux, and the reaction was maintained for 4 hours. 2. After completion of the reaction, the reaction mixture was filtered while hot. 3. The filtrate was distilled under reduced pressure to remove ethanol. 4. 4. After cooling, the product was extracted with ether. 5. 5. The extract was recrystallized from light petroleum ether (boiling point: 40-60 °C) to give purified 2-chloro-5-methoxypyrimidine (20 g, 58% yield).
References	[1] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24 [2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27

2-Chloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials	2,4-Dichloro-5-methoxypyrimidine-->Ethanol-->ZINC-->Water
Preparation Products	methyl 5-methoxypyrimidine-2-carboxylate-->2-Chloro-5-hydroxypyrimidine

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