| Company Name: |
Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548 |
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cwb1@biopurify.cn |
| Products Intro: |
Product Name:Norswertianolin
CAS:54954-12-0
Purity:>95%,98%,99% Package:From mgs to grams,up to Kgs.Inquire for Bulk scale.
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-164-7117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:1,3,5-Trihydroxy-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9H-xanthen-9-one
CAS:54954-12-0
Purity:98% Package:1mg;5mg;10mg;25mg;50mg Remarks:BD01097552
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| Company Name: |
Wuhan ChemFaces Biochemical Co., Ltd.
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| Tel: |
18607101326 15172504745 |
| Email: |
aileen@chemfaces.com |
| Products Intro: |
Product Name:Norswertianolin
CAS:54954-12-0
Purity:>=98% Package:5mg ,10mg ,20mg ,50mg ,100mg; 200mg; 500mg,可根据客户需求定制 Remarks:2028/5mg
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| | norswertianolin Basic information |
| Product Name: | norswertianolin | | Synonyms: | norswertianolin;9H-Xanthen-9-one, 8-(β-D-glucopyranosyloxy)-1,3,5-trihydroxy-;1,3,5-Trihydroxy-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9H-xanthen-9-one | | CAS: | 54954-12-0 | | MF: | C19H18O11 | | MW: | 422.34 | | EINECS: | | | Product Categories: | | | Mol File: | 54954-12-0.mol |  |
| | norswertianolin Chemical Properties |
| Melting point | 265 °C (decomp) | | Boiling point | 833.7±65.0 °C(Predicted) | | density | 1.789±0.06 g/cm3(Predicted) | | pka | 6.73±0.20(Predicted) | | form | Solid | | color | White to light yellow |
| | norswertianolin Usage And Synthesis |
| Uses | Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2]. | | Definition | ChEBI: A beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and <ital Gentiana germanica. | | in vivo | Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2].
Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2]. | Animal Model: | Male Sprague Dawley rats (10~12 weeks)[2] | | Dosage: | 4.4 mg/kg/day | | Administration: | S.c. | | Result: | Improved CSE/H2S production.
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| | References | [1] Ren K, et al. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. Biomed Res Int. 2019;2019:2692970. Published 2019 Jan 20. DOI:10.1155/2019/2692970
[2] Niu Y, et al. Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension. Front Pharmacol. 2021;12:677212. Published 2021 Jul 14. doi:10.3389/fphar.2021.677212 |
| | norswertianolin Preparation Products And Raw materials |
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