Pyridine-2-carboxylic acid hydrazide

Pyridine-2-carboxylic acid hydrazide Suppliers list

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

Company Name:	Beijing HwrkChemical Technology Co., Ltd
Tel:	89508211 18501085097
Email:	sales.bj@hwrkchemical.com

Company Name:	BeiJing Hwrk Chemicals Limted
Tel:	0757-86329057 18934348241
Email:	sales4.gd@hwrkchemical.com

Pyridine-2-carboxylic acid hydrazide manufacturers

Pyridine-2-carboxylic acid hydrazide Basic information

Product Name:	Pyridine-2-carboxylic acid hydrazide
Synonyms:	AKOS B014996;AKOS BBS-00004147;2-PICOLINYL HYDRAZIDE;ART-CHEM-BB B014996;PYRIDINE-2-CARBOHYDRAZIDE;2-pyridinecarboxylic acid hydrazide;2-PICOLINYL HYDRAZIDE 98+%;NSC-81875
CAS:	1452-63-7
MF:	C6H7N3O
MW:	137.14
EINECS:
Product Categories:	Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;AMIDE
Mol File:	1452-63-7.mol

Pyridine-2-carboxylic acid hydrazide Chemical Properties

Melting point	100°C
Boiling point	100-102 °C
density	1.244
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	11.29±0.10(Predicted)
color	White to Off-White
InChI	1S/C6H7N3O/c7-9-6(10)5-3-1-2-4-8-5/h1-4H,7H2,(H,9,10)
InChIKey	BAQLNPIEFOYKNB-UHFFFAOYSA-N
SMILES	NNC(=O)c1ccccn1
CAS DataBase Reference	1452-63-7(CAS DataBase Reference)

Safety Information

MSDS Information

Pyridine-2-carboxylic acid hydrazide Usage And Synthesis

Chemical Properties	White to off-white solid
Uses	Pyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.
Synthesis	2524-52-9 1452-63-7 General procedure for the synthesis of 2-pyridinecarbohydrazide from ethyl 2-pyridinecarboxylate: a mixed solution of ethyl pyridine-2-carboxylate (90 g) and hydrazine hydrate (60 g) in ethanol (400 ml) was reacted with stirring at 80°C for 4 hours. After completion of the reaction, the solvent was removed by evaporation to give the crude product. The crude product was co-stirred with ether and the resulting suspension was filtered and the wet filter cake was washed with a small amount of ethanol (50 mL) to give 76 g (93% yield) of 2-pyridinecarbohydrazide as a white solid. Mass spectral data: m/z 138.0 (M+H).
References	[1] Patent: WO2010/136971, 2010, A1. Location in patent: Page/Page column 12 [2] Patent: US2012/142710, 2012, A1. Location in patent: Page/Page column 6 [3] Patent: WO2012/76989, 2012, A1. Location in patent: Page/Page column 55; 64 [4] Asian Journal of Chemistry, 2010, vol. 22, # 7, p. 5535 - 5542 [5] Patent: WO2017/106427, 2017, A1. Location in patent: Page/Page column 37-38

Pyridine-2-carboxylic acid hydrazide Preparation Products And Raw materials

Raw materials	Ethyl acetate-->Methanol-->Dichloromethane-->Thionyl chloride-->Hydrazinium hydroxide solution-->2-Picolinic acid-->Butyl pyridine-2-carboxylate-->Ethyl picolinate-->Methyl picolinate-->Hydrazine hydrate
Preparation Products	3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine

Tag:Pyridine-2-carboxylic acid hydrazide(1452-63-7) Related Product Information

Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]- Pyridine, 3-(3-ethoxyandrosta-5,16-dien-17-yl)- Pyridine, 4-(diethylboryl)- Pyridine-3-sulfonyl chloride hydrochloride Isonicotinamide 3,5-bis(pyridin-4-yl)-4-amino-1,2,4-triazole 1-isonicotinyl-2-lactosylhydrazine Pyridine-2,4-dicarbonitrile 2,5-Bis(4-pyridyl)-1,3,4-oxadiazole Pyridine-2-carboxamide Pyridine-3-sulfonic acid sodium salt Pyridine-2,6-dicarbohydrazide Formylhydrazine Isoniazid 4-Chloro-pyridine-2-carboxylic acid hydrazide Pyridine-2-carboxylic acid hydrazide Nicotinic acid hydrazide 4-Chloropyridine-2,6-dicarbohydrazide