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| 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Basic information |
Product Name: | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one | Synonyms: | 1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-;4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene;AZATMint-D;4-(hidroximetil)-5-metil-1,3-dioxol-2-ona ISO 9001:2015 REACH;Azilsartan Impurity 55 | CAS: | 91526-18-0 | MF: | C5H6O4 | MW: | 130.1 | EINECS: | 1308068-626-2 | Product Categories: | | Mol File: | 91526-18-0.mol | |
| 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Chemical Properties |
Boiling point | 214℃ | density | 1.367 | Fp | 93℃ | storage temp. | Inert atmosphere,Store in freezer, under -20°C | solubility | Chloroform (Slightly), Methanol (Slightly) | form | liquid | pka | 14.54±0.10(Predicted) | color | Pale yellow | InChI | InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3 | InChIKey | JEQSUJXHFAXJOW-UHFFFAOYSA-N | SMILES | O1C(C)=C(CO)OC1=O |
| 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Usage And Synthesis |
Description | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug. | Definition | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group. | Uses | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil. | Preparation | At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.
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| 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials |
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