Company Name: |
Haoyuan Chemexpress Co., Ltd.
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021-58950125 |
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info@chemexpress.com |
Products Intro: |
Product Name:AICAR (phosphate) CAS:681006-28-0 Purity:>98% Package:520RMB/50mg
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| AICAR (phosphate) Basic information |
Product Name: | AICAR (phosphate) | Synonyms: | AICAR (phosphate);5-Amino-1-ribosylimidazole-4-carboxamide phosphate;AICAR (Acadesine) phosphate;AICAR phosphate, >98%;AICA Riboside phosphate);AICAR phosphate
(Acadesine phosphate;Acadesine phosphate;ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE | CAS: | 681006-28-0 | MF: | C9H17N4O9P | MW: | 356.23 | EINECS: | | Product Categories: | | Mol File: | 681006-28-0.mol | |
| AICAR (phosphate) Chemical Properties |
storage temp. | Store at -20°C | solubility | Soluble in DMSO | form | Solid | color | White to off-white |
| AICAR (phosphate) Usage And Synthesis |
Biological Activity | aicar phosphate (acadesine)is an activator of ampk [1].aicar phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the ec50 value is 380±60μm on the viability assay of b-cll cells. in addition, aicar phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in b-cll cells. furthermore, aicar phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate ampk. apart from these, aicar phosphate (2-4 mm) has shown to only slightly affects the viability of t cells from b-cll patients, aicar phosphate (0.5 mm) has been noted to remarkedly reduces viability of b cells but not t cells [1]. | references | [1] campàs c1, lopez jm, santidrián af, barragán m, bellosillo b, colomer d, gil j. acadesine activates ampk and induces apoptosis in b-cell chronic lymphocytic leukemia cells but not in t lymphocytes. blood. 2003 may 1;101(9):3674-80. epub 2003 jan 9. |
| AICAR (phosphate) Preparation Products And Raw materials |
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