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Methimazole

Methimazole Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
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Products Intro: Product Name:Methimazole
CAS:60-56-0
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:60-56-0
CAS:60-56-0
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555
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Products Intro: Product Name:2-Mercapto-1-methylimidazole
CAS:60-56-0
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:60-56-0
Purity:98% Package:g-Kg Remarks:White to white crystalline powder
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: CAS:60-56-0
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Lastest Price from Methimazole manufacturers

  • MethiaMazole
  • US $980.00 / KG
  • 2020-07-21
  • CAS:60-56-0
  • Min. Order: 1KG
  • Purity: 98.0%
  • Supply Ability: 1T
  • Methimazole
  • US $1.00 / KG
  • 2019-07-06
  • CAS:60-56-0
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
  • Methimazole
  • US $1.00 / KG
  • 2019-07-06
  • CAS:60-56-0
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 100KG
Methimazole Basic information
description Chemical properties Uses Production methods
Product Name:Methimazole
Synonyms:1-methyl-2-mercapto-imidazol;1-methyl-imidazole-2-thio;1-Metylo 2 merkaptoimidazolem;1-metylo2merkaptoimidazolem;LABOTEST-BB LT00033517;METHIAZOLE;METHIMAZOL;METHIMAZOLE
CAS:60-56-0
MF:C4H6N2S
MW:114.17
EINECS:200-482-4
Product Categories:Other APIs;Medicine Intermediates;TAPAZOLE;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles;M;API;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediates;Heterocyclic Compounds
Mol File:60-56-0.mol
Methimazole Structure
Methimazole Chemical Properties
Melting point 144-147 °C(lit.)
Boiling point 280 °C
density 1.176 (estimate)
refractive index 1.5000 (estimate)
Fp 280°C
storage temp. Refrigerator
solubility 200g/l
pka12.37±0.50(Predicted)
form Crystalline Powder
color White to slightly cream or pale buff
Water Solubility soluble
Merck 14,5971
BRN 108646
CAS DataBase Reference60-56-0(CAS DataBase Reference)
IARC3 (Vol. 79) 2001
NIST Chemistry ReferenceMethimazole(60-56-0)
EPA Substance Registry SystemMethimazole (60-56-0)
Safety Information
Hazard Codes Xn
Risk Statements 43-62-63-22
Safety Statements 26-27-36-45-36/37
WGK Germany 3
RTECS NI8615000
TSCA Yes
HS Code 29332990
Hazardous Substances Data60-56-0(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Methimazole English
ACROS English
SigmaAldrich English
ALFA English
Methimazole Usage And Synthesis
descriptionMethimazole is an antithyroid medication used in the therapy of hyperthyroidism and Graves disease. It works by making it harder for the body to make thyroid hormone.
It is also known as thiamazole, is a thioamide and a thyroid hormone antagonist which acts by inhibiting the incorporation of iodine into tyrosyl residues of thyroglobulin and, thus, lowering thyroid hormone levels.
It resembles propylthiouracil both in chemical structure and activity.
Methimazole is primarily used for the treatment of hyperthyroidism, by inhibiting the peroxidase system, hindering thyroxine (T4) and tri-triiodothyronine (T3) synthesis, animal experiments show that it can inhibit B lymphocytes synthesizing antibodies, and reduce levels of thyroid stimulating antibodies in blood circulating it can make suppressing T cell function return to normal, it is applicable to hyperthyroidism caused by a variety of factors . Like other various drugs (propylthiouracil), it also has some adverse reactions while it is taken, Including hematologic adverse reactions, primarily neutropenia, hematopoietic dysfunction or disorder, thrombocytopenia, reduction of prothrombin or factor VII ; long-term medication can also cause liver damage,such as cholestatic jaundice and toxic hepatitis ; other skin reactions such as hair loss, itching, rash, dermatitis, lupus erythematosus, as well as some other rare adverse reactions. Also methimazole allows prothrombin time to prolong , and increases serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)and causes blood bilirubin and blood lactate dehydrogenase increasing. Therefore, patients in the medication should regularly take blood tests, liver function tests and peripheral blood leukocytes.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical propertiesleaf-shaped crystalline (ethanol), melting point 146-148 ℃, boiling point 280 ℃ (decomposition), soluble in water, soluble in alcohol, chloroform, slightly soluble in ether, benzene.
UsesCarbimazole intermediates.
anti-thyroid drugs.
Production methodsReact amino acetal with methyl isothiocyanate to genarate this product. The product can also be produced from thiocyanate and N-substituted amino acetal.
Chemical PropertiesWhite Solid
OriginatorFavistan ,Asta
UsesMethimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid
Manufacturing Process2 Methods of preparation of thiamazole:
1. To 2,2-diethoxyethylamine methylisothiocyanate was added and mixed after then 1-(2,2-diethoxy-ethyl)-3-methylthiourea was obtained.
The reaction of the 1-(2,2-diethoxyethyl)-3-methylthiourea with sulfuric acid yield thiamazole.
2. 1,1-Diethoxyethane was treated by bromine in the presence CaCO3 and 2- bromo-1,1-diethoxyethane was obtained.
Then to the 2-bromo-1,1-diethoxyethane methylamine was added, mixed and reaction mixture was heated to 120°-130°C in autoclave. As the result (2,2- diethoxyethyl)methylamine was obtained.
(2,2-Diethoxyethyl)methylamine reacted with potassium thiocyanate in the presence of hydrochloric acid and give the thiamazole, yellow crystallic precipitate, melting point 144°-147°C.
Brand nameTapazole (Jones); Tapazole (King) .
Therapeutic FunctionThyroid inhibitor
General DescriptionMethimazole, 1-methylimidazole-2-thiol (Tapazole), occurs as a white to off-white, crystallinepowder with a characteristic odor and is freely soluble inwater. A 2% aqueous solution has a pH of 6.7 to 6.9. It shouldbe packaged in well-closed, light-resistant containers.
Clinical UseMethimazole is indicated in the treatment of hyperthyroidism.It is more potent than propylthiouracil. The side effectsare similar to those of propylthiouracil. As with otherantithyroid drugs, patients using this drug should be undermedical supervision. Also, like the other antithyroid drugs,methimazole is most effective if the total daily dose is subdividedand given at 8-hour intervals.
Safety ProfilePoison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.
Veterinary Drugs and TreatmentsMethimazole is considered by most clinicians to be the agent of choice when using drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to methimazole and is rarely used today. Transdermal methimazole (in PLO gel; 2.5 mg twice daily) has been used with some therapeutic success in cats that do not tolerate oral dosing. Efficacy may require four or more weeks to detect. Studies are ongoing.
Methimazole appears to be useful for the prophylactic prevention of cisplatin induced nephrotoxicity in dogs.
Purification MethodsCrystallise it from EtOH. UV: at 251nm (H2O), 260nm (EtOH) and 267nm (CHCl3). [Lawson max & Morley J Chem Soc 1103 1956, Beilstein 24 H 17, 24 III/IV 61.]
Methimazole Preparation Products And Raw materials
Raw materialsMethylamine-->Potassium thiocyanate-->Methyl isothiocyanate-->2,2-Diethoxyethylamine-->Sulfuric acid-->Hydrochloric acid
Tag:Methimazole(60-56-0) Related Product Information
2-MERCAPTO-1-METHYLIMIDAZOLE Methimazole Glucuronide,Methimazole Thio-b-D-glucuronide,Methimazole Glucuronid,Methimazole Thio--D-glucuronide THIAMAZOL IMPURITY A ETHYL 2-MERCAPTO-1-METHYLIMIDAZOLE-5-CARBOXYLATE 5-(HYDROXYMETHYL)-2-MERCAPTO-1-METHYLIMIDAZOLE,2-Mercapto-1-methylimidazole-5-methanol 1-Methyl-2-imidazolidinethione Methimazole-D3 THIAMAZOL IMPURITY C 2-MERCAPTO-4-METHYLIMIDAZOLE Methimazole Malathion 2-Mercaptoethanol Imidazole 1-Methylimidazole N-(Trimethylsilyl)imidazole 2-Ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate Mercaptoacetic acid 2-Methylimidazole