DBCO-PEG5-NHS ester manufacturers
|
| | DBCO-PEG5-NHS ester Basic information |
| Product Name: | DBCO-PEG5-NHS ester | | Synonyms: | DBCO-PEG5-NHS ester;Azadibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester;DBCO-NH-PEG4-CH2CH2COONHS ester;DBCO-NHCO-PEG5-NHS ester;4,7,10,13,16-Pentaoxa-20-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-19,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 1-[(3-{2-azatricyclo[10.4.0.0\\u2074,\\u2079]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)carbamoyl]-3,6,9,12,15-pentaoxaoctadecan-18-oate;DBCO-PEG5-NHS Ester (CCT-A102P);DBCO-PEG5-PA-NHS | | CAS: | 1378531-80-6 | | MF: | C36H43N3O11 | | MW: | 693.74 | | EINECS: | | | Product Categories: | | | Mol File: | 1378531-80-6.mol |  |
| | DBCO-PEG5-NHS ester Chemical Properties |
| density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Acetonitrile (Slightly), Chloroform (Slightly) | | form | Oil | | pka | 15.14±0.46(Predicted) | | color | Yellow to Dark Yellow |
| | DBCO-PEG5-NHS ester Usage And Synthesis |
| Description | DBCO-NHCO-PEG5-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions. | | Uses | DBCO-NHCO-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | DBCO-PEG5-NHS ester Preparation Products And Raw materials |
|