- CeMMEC1
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- $30.00 / 10mg
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2026-01-09
- CAS:440662-09-9
- Min. Order:
- Purity: 98.90%
- Supply Ability: 10g
- CeMMEC1
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- $0.01 / 1KG
-
2020-01-10
- CAS:440662-09-9
- Min. Order: 1KG
- Purity: 98%; 99%
- Supply Ability: 500g;1kg； 25kg
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| | CeMMEC1 Basic information |
| Product Name: | CeMMEC1 | | Synonyms: | CeMMEC1;4-Isoquinolinecarboxamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-;CeMMEC1(free base);cemmecl;Epigenetic Reader Domain,CeMMEC-1,Inhibitor,DNA/RNA Synthesis,CeMMEC1,inhibit,CeMMEC 1;N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide;CeMMEC1, 10 mM in DMSO | | CAS: | 440662-09-9 | | MF: | C19H16N2O4 | | MW: | 336.34 | | EINECS: | | | Product Categories: | | | Mol File: | 440662-09-9.mol |  |
| | CeMMEC1 Chemical Properties |
| Boiling point | 590.1±50.0 °C(Predicted) | | density | 1.386±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 11.38±0.20(Predicted) | | color | White to off-white |
| | CeMMEC1 Usage And Synthesis |
| Description | CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (Kd = 1.8 μM; IC50 = 0.9 μM). It does not bind to either the first or second bromodomain of BRD4. This compound synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells. | | Uses | CeMMEC1, shows high affinity for TAF1, and is an inhibitor of BRD4. | | storage | Store at -20°C | | References | [1] SARA SDELCI. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk[J]. Nature chemical biology, 2016, 12 7: 504-510. DOI: 10.1038/nchembio.2080 |
| | CeMMEC1 Preparation Products And Raw materials |
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