SIB 1553A manufacturers
- SIB 1553A
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- $117.00
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2026-07-31
- CAS:191611-76-4
- Purity: 99.79%
- Supply Ability: 10g
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| | SIB 1553A Basic information |
| Product Name: | SIB 1553A | | Synonyms: | SIB 1553A;Phenol, 4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]-;SIB 1553A, 10 mM in DMSO | | CAS: | 191611-76-4 | | MF: | C13H20ClNOS | | MW: | 237.36 | | EINECS: | | | Product Categories: | | | Mol File: | 191611-76-4.mol |  |
| | SIB 1553A Chemical Properties |
| Boiling point | 374.0±17.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | pka | 9.70±0.26(Predicted) |
| | SIB 1553A Usage And Synthesis |
| Uses | SIB-1553A free base is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A free base is also a selective neuronal nAChR ligand. SIB-1553A free base is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders[1][2]. | | References | [1] Vernier JM, et al. 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1999 May 20;42(10):1684-6. DOI:10.1021/jm990035d
[2] Rao TS, et al. In vitro pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 2003 Aug 15;981(1-2):85-98. DOI:10.1016/s0006-8993(03)02979-2
[3] Rao TS, et al. In vivo pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies. Brain Res. 2003 Oct 3;986(1-2):71-81. DOI:10.1016/s0006-8993(03)03174-3 |
| | SIB 1553A Preparation Products And Raw materials |
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