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| ALPHA-BUNGAROTOXIN Basic information |
Product Name: | ALPHA-BUNGAROTOXIN | Synonyms: | ALPHA-BUNGAROTOXIN;ALPHA-BUNGAROTOXIN, BUNGARUS MULTICINCTUS;ALPHA-BUTX;ALPHA-BGT;A-BUNGAROTOXIN;M.W. 7984.14 C338H529N97O105S11;H-ILE-VAL-CYS-HIS-THR-THR-ALA-THR-SER-PRO-ILE-SER-ALA-VAL-THR-CYS-PRO-PRO-GLY-GLU-ASN-LEU-CYS-TYR-ARG-LYS-MET-TRP-CYS-ASP-ALA-PHE-CYS-SER-SER-ARG-GLY-LYS-VAL-VAL-GLU-LEU-GLY-CYS-ALA-ALA-THR-CYS-PRO-SER-LYS-LYS-PRO-TYR-GLU-GLU-VAL-THR-CYS-CYS-SER-THR-ASP-LYS-CYS-ASN-PRO-HIS-PRO-LYS-GLN-ARG-PRO-GLY-OH;BUNGARUS MULTICINCTUS TOXIN, ALPHA | CAS: | 11032-79-4 | MF: | C50H70O14 | MW: | 895.0824 | EINECS: | 234-266-6 | Product Categories: | Acetylcholine receptor | Mol File: | 11032-79-4.mol | |
| ALPHA-BUNGAROTOXIN Chemical Properties |
storage temp. | −20°C | solubility | Soluble in sterile water | form | solid | color | white | Water Solubility | Soluble in water | CAS DataBase Reference | 11032-79-4 |
WGK Germany | 3 | RTECS | QQ4495249 | Toxicity | chicken,LD50,intramuscular,74ug/kg (0.074mg/kg),Toxicon. Vol. 7, Pg. 89, 1969. |
| ALPHA-BUNGAROTOXIN Usage And Synthesis |
Chemical Properties | Single polypeptide weight; molecular
weight of 8000. | Definition | A protein that binds specifically to acetylcholine
receptors. | General Description | Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 μM). | Hazard | Nuerotoxic. | Biochem/physiol Actions | Product does not compete with ATP. | storage | -20°C (desiccate) |
| ALPHA-BUNGAROTOXIN Preparation Products And Raw materials |
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