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| | 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE Basic information |
| Product Name: | 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE | | Synonyms: | 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE;7-azaindoline;1H-Pyrrolo[2,3-b]pyridine,2,3-dihydro-(6CI,8CI,9CI);2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine 7-azaindoline;1H,2H,3H-pyrrolo[2,3-b]pyridine;2,3-Dihydropyrrolo[2,3-b]pyridine, 97+%;1H-Pyrrolo[2,3-b]pyridine, 2,3-dihydro-;2,3-Dihydro-7-azaindole 98% | | CAS: | 10592-27-5 | | MF: | C7H8N2 | | MW: | 120.15 | | EINECS: | | | Product Categories: | PYRROLIDINE;API intermediates | | Mol File: | 10592-27-5.mol | ![2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE Structure](CAS/GIF/10592-27-5.gif) |
| | 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties |
| Melting point | 78-83 °C | | Boiling point | 114°C/10mmHg(lit.) | | density | 1.23 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | Powder | | pka | 10.75±0.20(Predicted) | | color | White | | Water Solubility | Slightly soluble in water. | | λmax | 306nm(Cyclohexane)(lit.) | | InChI | 1S/C7H8N2/c1-2-6-3-5-9-7(6)8-4-1/h1-2,4H,3,5H2,(H,8,9) | | InChIKey | ZFFYPGZDXUPKNK-UHFFFAOYSA-N | | SMILES | C1Cc2cccnc2N1 |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE Usage And Synthesis |
| Chemical Properties | Beige powder | | Uses | It can be used as pharmaceutical raw material and intermediate. | | Synthesis | a) 7-azaindole (100 g, 0.846 mol), Ni/AlO catalyst (12 g, 10 wt%), and toluene (200 g) were added to the autoclave and stirred and mixed homogeneously to obtain the reaction solution A; b) the autoclave was replaced with nitrogen for 8 times, followed by hydrogen for 4 times to ensure that the reaction system was oxygen-free; c) the reaction solution A was subjected to hydrogenation reaction at a pressure of 2 MPa hydrogen and 130 °C; d) after the completion of the reaction, the hydrogenation mixture was filtered to remove the catalyst to obtain the filtrate B; e) after distillation and recovery of the organic solvent from the filtrate B, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine (94.59 g, 93.4% yield) was obtained, and the purity of the product was analyzed by gas chromatography, which was ≥98%. | | References | [1] Patent: CN107987076, 2018, A. Location in patent: Paragraph 0043-0047; 0058-0063; 0075-0079
[2] Patent: CN106188050, 2016, A. Location in patent: Paragraph 0016
[3] Patent: US2011/144105, 2011, A1. Location in patent: Page/Page column 16
[4] Synthesis, 2005, # 15, p. 2503 - 2506
[5] Patent: WO2004/78757, 2004, A2. Location in patent: Page 32; 48-49 |
| | 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials |
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