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| | 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Basic information |
| Product Name: | 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE | | Synonyms: | SALOR-INT L161004-1EA;3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE;3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE;Windorphen;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrolein;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)prop-2-enal;(Z)-3-chloro-2,3-bis(4-Methoxyphenyl)acrylaldehyde;Windorphen - CAS 19881-70-0 - Calbiochem | | CAS: | 19881-70-0 | | MF: | C17H15ClO3 | | MW: | 302.75 | | EINECS: | | | Product Categories: | | | Mol File: | 19881-70-0.mol |  |
| | 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Chemical Properties |
| Melting point | 160-163°C | | Boiling point | 468.1±45.0 °C(Predicted) | | density | 1.198±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | color | white to beige |
| WGK Germany | 3 | | HazardClass | IRRITANT |
| | 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Usage And Synthesis |
| Uses | Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with?β-catenin,?blocking the Wnt signal required for ventral development. | | Biological Activity | windorphen is a wnt inhibitor that selectively abrogates the wnt signaling for ventral development.wnt protein is a family of signaling proteins that interacts on the wnt/β-catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.in canonical wnt/β-catenin reporter cell line stf293, windorphen dose-dependently inhibits wnt3a-inducible topflash-luciferase activity (ic50 of 1.5 mm). in human colon adenocarcinomasw480 cells with defective apc gene that constitutively activates wnt signaling, 72 h treatment of windorphen causes a wide spread apoptosis. [1]in zebrafish embryos, windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). windorphen selectively inhibits wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). in addition, windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective axin1/β-catenin destruction complex causes abnormal activation of wnt signaling and the loss of telencephalon and eyes.) [1] | | references | 1. hao j, ao a, zhou l et al. selective small molecule targeting β-catenin function discovered by invivo chemical genetic screen. cell rep. 2013 sep 12;4(5):898-904. |
| | 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Preparation Products And Raw materials |
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