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Duloxetine

Duloxetine Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Duloxetine
CAS:116539-59-4
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:116539-59-4
CAS:116539-59-4
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Duloxetine
CAS:116539-59-4
Purity:98% Package:25KG;100USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:(S)-duloxetine
CAS:116539-59-4
Purity:0.99 Package:5KG;1KG Remarks:C18H20ClNOS
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:Duloxetine
CAS:116539-59-4
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg

Lastest Price from Duloxetine manufacturers

  • Duloxetine
  • US $1.00 / KG
  • 2020-01-17
  • CAS:116539-59-4
  • Min. Order: 1KG
  • Purity: 85.0-99.8%
  • Supply Ability: 200kgs
  • Duloxetine
  • US $100.00 / KG
  • 2019-07-06
  • CAS:116539-59-4
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1000KG
Duloxetine Basic information
Product Name:Duloxetine
Synonyms:DULOXETINE;DULOXETINE-D3;(S)-DULOXETINE;DULOXETIN;(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine;N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine;DULOXETINE HCI;Duloxetine & Intermediates
CAS:116539-59-4
MF:C18H19NOS
MW:297.41
EINECS:601-438-0
Product Categories:API;ACTIVE PHARMACEUTICAL INGREDIENTS
Mol File:116539-59-4.mol
Duloxetine Structure
Duloxetine Chemical Properties
Boiling point 466.2±40.0 °C(Predicted)
density 1.158±0.06 g/cm3(Predicted)
pka10.02±0.10(Predicted)
EPA Substance Registry System2-Thiophenepropanamine, N-methyl-?-(1-naphthalenyloxy)-, (?S)- (116539-59-4)
Safety Information
Hazardous Substances Data116539-59-4(Hazardous Substances Data)
MSDS Information
Duloxetine Usage And Synthesis
UsesAntidepressant.
Brand nameCymbalta (Lilly).
General DescriptionDuloxetine (Cymbalta) is a newer antidepressant. It islargely like venlafaxine, which is an SNERI (selective norepinephrinereuptake inhibitor).
PharmacokineticsDuloxetine appears to be fairly well absorbed after oral doses, with peak plasma levels in 6 to 10 hours and linear pharmacokinetics. The drug is extensively metabolized in the liver to active metabolites, with 72% of an oral dose primarily excreted in the urine as conjugated metabolites and up to 15% appearing in the feces.
N-demethylation to an active metabolite (CYP2D6) and hydroxylation of the naphthyl ring (CYP1A2) at either the 4-, 5-, or 6-positions are the main metabolic pathways for duloxetine. Its metabolites are primarily excreted into the urine as glucuronide, sulfate, and O-methylated conjugation products. The major metabolites found in plasma also were found in the urine. Preclinical data for 4-hydroxyduloxetine suggests it has a similar pharmacological profile to duloxetine, with selective inhibition of SERT but less activity at the NET.
Clinical UseDuloxetine has been approved for the treatment of depression and diabetic peripheral neuropathic pain. It is another analogue in the line of fluoxetine-based products from Lilly, in which the phenyl and phenoxy groups of fluoxetine have been respectively replaced with the benzene isostere, thiophene, and a naphthyloxy group (previously described under fluoxetine). Duloxetine exhibits dual inhibition with high affinity for the SERTs and NETs, with a five times preferential inhibition of the SERT. Duloxetine appears to be a more potent in vitro blocker of SERTs and NETs than venlafaxine. In humans, duloxetine has a low affinity for the other neuroreceptors, suggesting low incidence of unwanted adverse effects.
Duloxetine Preparation Products And Raw materials
Raw materials1-Fluoronaphthalene
Tag:Duloxetine(116539-59-4) Related Product Information
Paroxetine (r)-duloxetine,R-DULOXETINE HCL,(r)-n-methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine N-METHYL DULOXETINE-NAPHTHYL-D7 Duloxetine-naphthyl-D7 Maleate DULOXETINE HCL PELLETS Duloxetine intermediate Duloxetine intermediate AA Duloxetine hydrochoride (rs)-duloxetine hydrochloride,(rs)-n-methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride 4-Hydroxy duloxetine glucuronide Duloxetine-d3 HCl R-DULOXETINE HYDROCHLORIDE (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine DULOXETINE-NAPHTHYL-D7 5-Hydroxy-6-methoxy duloxetine sulfate 4-Hydroxy Duloxetine 4-Hydroxy Duloxetine -D-Glucuronide,4-Hydroxy Duloxetine b-D-Glucuronide S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE