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Benzeneethanamine, 3,4-difluoro- (9CI) manufacturers
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| | Benzeneethanamine, 3,4-difluoro- (9CI) Basic information |
| Product Name: | Benzeneethanamine, 3,4-difluoro- (9CI) | | Synonyms: | Benzeneethanamine, 3,4-difluoro- (9CI);BenzeneethanaMine, 3,4-difluoro-;2-(3,4-Difluorophenyl)ethanamine;2-(3,4-Difluorophenyl)ethylamine;3,4-Difluoro-benzeneethanaMine;BENZENEETHANAMINE,3,4-DIFLUORO- (CAS NO.220362-31-2);2-(3,4-fluorophenyl)ethanamine;2-(3,4-fluorophenyl)ethylamine | | CAS: | 220362-31-2 | | MF: | C8H9F2N | | MW: | 157.16 | | EINECS: | | | Product Categories: | HALIDE | | Mol File: | 220362-31-2.mol |  |
| | Benzeneethanamine, 3,4-difluoro- (9CI) Chemical Properties |
| Boiling point | 203℃ | | density | 1.169 | | Fp | 91℃ | | storage temp. | 2-8°C(protect from light) | | solubility | Acetonitrile (Slightly), Chloroform (Slightly) | | form | Oil | | pka | 9.25±0.10(Predicted) | | color | Colourless |
| | Benzeneethanamine, 3,4-difluoro- (9CI) Usage And Synthesis |
| Synthesis | Synthesis of intermediate 2-(3,4-difluorophenyl)ethylamine (I-49b): the preparation and post-treatment steps were carried out with reference to the preparation of intermediate I-15b. The specific operation was as follows: E-1,2-difluoro-4-(2-nitrovinyl)benzene (I-49a, 5 g, 27.027 mmol) was dissolved in anhydrous THF (81 mL), and LiBH4 (2.35 g, 108.1081 mmol) and chlorotrimethylsilane (27.63 mL, 216.216 mmol) were added sequentially at 0 °C. The reaction mixture was stirred at room temperature for 3 days. Upon completion of the reaction, 4.2 g of the target product was obtained by post-processing in 100% yield. The product was characterized by 1H NMR (DMSO, 300 MHz): δ 8.7 (broad peak, 2H), 7.5-7.3 (multiple peaks, 2H), 7.2-7.0 (multiple peaks, 1H), 3.0-2.8 (multiple peaks, 4H).LCMS analysis showed a purity of 98.87%, m/z = 158.1 (M + 1). | | References | [1] Patent: US2014/45872, 2014, A1. Location in patent: Paragraph 0814
[2] Patent: WO2008/39882, 2008, A1. Location in patent: Page/Page column 191 |
| | Benzeneethanamine, 3,4-difluoro- (9CI) Preparation Products And Raw materials |
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