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| | PMPA(NAALADaseinhibitor) Basic information |
| Product Name: | PMPA(NAALADaseinhibitor) | | Synonyms: | PMPA(NAALADaseinhibitor);2-(Phosphonomethyl)pentane-1,5-dioicacid;2-PMPA;CS-2454;2-PMPA(NAALADaseinhibitor);NAALADASEINHIBITOR;Pentanedioic acid, 2-(phosphonomethyl)-;2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA) | | CAS: | 173039-10-6 | | MF: | C6H11O7P | | MW: | 226.12 | | EINECS: | | | Product Categories: | | | Mol File: | 173039-10-6.mol |  |
| | PMPA(NAALADaseinhibitor) Chemical Properties |
| Boiling point | 538.8±60.0 °C(Predicted) | | density | 1.658±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | Soluble to 100 mM in sterile | | pka | 2.06±0.10(Predicted) | | form | powder | | color | white to beige | | Water Solubility | Soluble to 100 mM in water |
| | PMPA(NAALADaseinhibitor) Usage And Synthesis |
| Uses | 2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia. | | Biological Activity | Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO). | | Biochem/physiol Actions | 2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII). | | storage | Desiccate at RT |
| | PMPA(NAALADaseinhibitor) Preparation Products And Raw materials |
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