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| | TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Basic information |
| Product Name: | TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE | | Synonyms: | 4,5,6,7-tetrahydro-5-Boc-thiazolo[5,4-c]pyridin-2-amine;2-Amino-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester;4-c]pyridine-5(4H)-carboxylate;7-dihydrothiazolo[5;tert-butyl 2-aMino-6;tert-butyl 2-aMino-6.7-dihydrothiazolo[5.4-c]pyridine-5(4H)-carb;2-AMino-5-Boc-6,7-dihydro-4H-thiazolo-[5,4,c]pyridine;tert-butyl 2-aMino-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate | | CAS: | 365996-05-0 | | MF: | C11H17N3O2S | | MW: | 255.34 | | EINECS: | | | Product Categories: | Heterocycle-Pyridine series;CHIRAL CHEMICALS | | Mol File: | 365996-05-0.mol | ![TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Structure](CAS/GIF/365996-05-0.gif) |
| | TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Chemical Properties |
| Melting point | 91-94 °C | | Boiling point | 412.8±45.0 °C(Predicted) | | density | 1.279±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Crystalline Powder | | pka | 5.23±0.20(Predicted) | | color | Off-white to brown | | InChI | InChI=1S/C11H17N3O2S/c1-11(2,3)16-10(15)14-5-4-7-8(6-14)17-9(12)13-7/h4-6H2,1-3H3,(H2,12,13) | | InChIKey | BMLHPGOMLGKYIJ-UHFFFAOYSA-N | | SMILES | C1N(C(OC(C)(C)C)=O)CCC2N=C(N)SC1=2 |
| | TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Usage And Synthesis |
| Uses | 2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carboxylic Acid tert-Butyl Ester is a reagent used in the synthesis of 2-(thiazol-2-amino)-4-arylaminopyrimidines, which are anaplastic lymphoma kinase (ALK) inhibitors. | | Synthesis | To a 100 mL single-necked flask were added N-Boc-4-piperidone (10 g, 50 mmol), sulfur powder (3.22 g, 100 mmol), cyanamide (4.36 g, 100 mmol), and pyridine (40 mL). The reaction mixture was heated to 130 °C and kept for 90 min. After completion of the reaction, it was cooled to room temperature and the solid product was collected by filtration. The solid was washed with ethyl acetate and dried to give the dark brown solid product tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (9.7 g, 76% yield). | | References | [1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0339; 0340; 0341
[2] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 128 - 152
[3] Patent: WO2014/113191, 2014, A1. Location in patent: Paragraph 0124; 0125
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[5] Heterocycles, 2004, vol. 63, # 7, p. 1555 - 1561 |
| | TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Preparation Products And Raw materials |
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