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Pyrrolidine Suppliers list
Company Name: Hebei Crovell Biotech Co Ltd
Tel: +86-19930503285 +86-19930503285
Products Intro: Product Name:Pyrrolidine
Purity:99.% Package:1KG;10.00;USD
Company Name: Yunbio Tech Co.,Ltd.
Tel: +8618046518538
Products Intro: Product Name:Pyrrolidine
Purity:99% Package:10kg,100kg,1ton,10ton,100ton Remarks:Fine Chemical
Company Name: Hebei shuoxi biotechnology co. LTD
Tel: +8613081092107
Products Intro: Product Name:Pyrrolidine
Purity:99.9% Package:1KG;USD
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-19930503282 +86-19930503282
Products Intro: Product Name:Pyrrolidine
Purity:99%min Package:25Kg/Drum;100USD Remarks:/
Company Name: Shanghai Dumi Biotechnology Co.,ltd
Tel: +8617172178855 17172178855
Products Intro: Product Name:Pyrrolidine
Purity:99.9% Package:1KG;80USD

Pyrrolidine manufacturers

  • Tetrahydro pyrrole
  • $5.00 / 25kg
  • 2023-01-20
  • CAS:123-75-1
  • Min. Order: 1kg
  • Purity: ≥99%
  • Supply Ability: 100mt/year
  • Pyrrolidine
  • $0.00 / 1kg
  • 2023-01-14
  • CAS:123-75-1
  • Min. Order: 1kg
  • Purity: 99.9%
  • Supply Ability: 20 tons/month
  • Pyrrolidine
  • $20.00 / 1Kg/Drum
  • 2023-01-13
  • CAS:123-75-1
  • Min. Order: 1Kg/Drum
  • Purity: 99%
  • Supply Ability: 1000kg/month

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Pyrrolidine Basic information
Product Name:Pyrrolidine
Synonyms:tetrahydro-pyrrol;Tetramethylenimin;Tetramethylenimine;LABOTEST-BB LTBB000397;pyrrolidine,tetrahydropyrrole;PYRROLIDINE,REAGENT;TETRAHYDROPYRROLE(PYRROLIDINE);PYRROLIDINE 99+%
Product Categories:Building Blocks;C4 to C8;Aliphatics;Chemical Synthesis;Heterocyclic Building Blocks;Pyrrolidines;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Flavor;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;123-75-1
Mol File:123-75-1.mol
Pyrrolidine Structure
Pyrrolidine Chemical Properties
Melting point -63 °C
Boiling point 87-88 °C/760 mmHg (lit.)
density 0.852 g/mL at 25 °C (lit.)
vapor density 2.45 (vs air)
vapor pressure 128 mm Hg ( 39 °C)
refractive index n20/D 1.443(lit.)
Fp 37 °F
storage temp. Store below +30°C.
solubility water: miscible
form Liquid
pka11.27(at 25℃)
color Colorless to Almost colorless
PH12.9 (100g/l, H2O, 20℃)
explosive limit1.6-10.6%(V)
Water Solubility Miscible with alcohol, ether, chloroform and water.
Sensitive Air Sensitive
Merck 14,8015
JECFA Number1609
BRN 102395
Stability:Stable; flammable. Incompatible with strong acids, strong oxidizing agents.
LogP0.22 at 25℃
CAS DataBase Reference123-75-1(CAS DataBase Reference)
NIST Chemistry ReferencePyrrolidine(123-75-1)
EPA Substance Registry SystemPyrrolidine (123-75-1)
Safety Information
Hazard Codes F,T,C
Risk Statements 11-22-23-34-35-20/21/22-20/22-R35-R20/21/22-R11
Safety Statements 16-26-36/37/39-45-33-S45-S36/37/39-S26-S16
RIDADR UN 1922 3/PG 2
WGK Germany 2
RTECS UX9650000
Autoignition Temperature653 °F
HS Code 2933 99 80
HazardClass 3
PackingGroup II
Hazardous Substances Data123-75-1(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 433 mg/kg
MSDS Information
ACROS English
SigmaAldrich English
ALFA English
Pyrrolidine Usage And Synthesis
Chemical PropertiesPyrrolidine is acolourless to pale yellow liquid with a penetrating, It is infinitely miscible with water and conventional organic solvents such as methanol, acetone, ether, and chloroform. It acts as a lachrymator.
Chemically, pyrrolidine behaves like a secondary amine in every respect. For example, it undergoes Leuckart – Wallach and Mannich reactions and is readily converted into an enamine. In the presence of a catalyst, such as platinum at 360°C or rhodium at 650°C, pyrrole is formed. In the presence of a copper catalyst, N-methylpyrrolidone is converted into Nmethylpyrrolidine.
Physical propertiesPyrrolidine has a penetrating amine-type odor, reminiscent of ammonia and piperidine. It is easy to turn yellow when exposed to light or humid air, easily soluble in water and ethanol. It is nauseating and diffusive.
OccurrenceReported found in beer, bread, wheat bread, salmon caviar, fish, milk, leaves and stalks of celery, Camembert cheese, Limburger cheese, Russian cheeses, tilsit cheese, other cheeses, caviar, raw fatty fish, beer, Finnish whiskey, white wine, red wine, coffee, radish, malt, roasted peanut, sweet corn and roasted barley.
UsesPyrrolidine is a flammable alkaline liquid that undergoes reactions typical of secondary amines. It is used to prepare pesticides and rubber accelerators and as a chemical intermediate (usually the hydrochloride form) in the pharmaceutical industry. There is relatively limited industrial exposure to this material.
ApplicationPyrrolidine is a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs). It has been used for the synthesis of N-benzoyl pyrrolidine from benzaldehyde via oxidative amination. It may be used as a catalyst for the synthesis of N-sulfinyl aldimines from carbonyl compounds and sulfonamides.
Pyrrolidine can also be used to synthesize:
Taddol-pyrrolidine phosphoramidite, a ligand for rhodium-catalyzed [2+2+2] cycloaddition of pentenyl isocyanate and 4- ethynylanisole.
H,4 PyrrolidineQuin-BAM (′PBAM′), a selective catalyst for the aza-Henry addition of nitroalkanes to aryl aldimines.
1,2,3,3a,4,9-Hexahydropyrrolo[2,1-b]quinazoline by reacting with o-aminobenzaldehyde.
PreparationPyrrolidine is formed by reduction of pyrrole. Via overall 5-endo-trig cyclizations of homoallylic tosylamides. Pyrrolidine can be produced from butanediol and ammonia, e.g., over an aluminum thorium oxide catalyst at 300°C or over a nickel catalyst at 200°C and 20 MPa under hydrogenation conditions. It can also be produced from THF and ammonia over aluminum oxide at 275-375°C.
DefinitionChEBI: Pyrrolidine is a cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family. It is a saturated organic heteromonocyclic parent, a member of pyrrolidines and an azacycloalkane. It is a conjugate base of a pyrrolidinium ion.
Aroma threshold valuesDetection: 20.2 ppm
Taste threshold valuesTaste characteristics at 50 ppm: ammonia and fishy, amine-like with seaweed and shellfish nuances.
General DescriptionPyrrolidine is a saturated heterocycliccompound having one nitrogenatom in a five-membered ring. It is a colorless to pale yellow liquid with an ammonia-like odor. It is found in certain plants andthe ring structure is present in manyalkaloids. Flash point 37°F. Density 0.85 g / cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.
Air & Water ReactionsHighly flammable. Very soluble in water.
Reactivity ProfileTetrahydro pyrrole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of Tetrahydro pyrrole, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.
HazardFlammable, dangerous fire risk. Toxic by ingestion and inhalation.
Health HazardThe acute toxicity of pyrrolidine is moderateon test animals. It is somewhat less toxicthan pyrrole. The vapors are an irritant tothe eyes and respiratory tract. The liquid iscorrosive to the skin. Contact with the eyescan cause damage. The oral LD50 value inrats is 300 mg/kg, while the inhalation LC50value in mice is 1300 mg/m3/2 h (NIOSH1986).
Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and ExplosibilityHighlyflammable
Safety ProfilePoison by ingestion and intravenous routes. Moderately toxic by inhalation. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx.
Purification MethodsDry pyrrolidine with BaO or sodium, then fractionally distil it, under N2, through a Todd column (p 11) packed with glass helices. [Beilstein 20 H 159, 20 I 36, 20 II 79, 20 III/IV 2072, 20/1 V 162.]
Tag:Pyrrolidine(123-75-1) Related Product Information
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