ChemicalBook > Product Catalog >Flavors and fragrances >Synthetic fragrances >Oxygen-containing heterocyclic compounds >Thiazole, thiophene, and pyridine >Pyrrolidine


Pyrrolidine Suppliers list
Company Name: Yunbio Tech Co.,Ltd.
Tel: 010-60605551
Products Intro: Product Name:Pyrrolidine
Purity:99% Package:10kg,100kg,1ton,10ton,100ton Remarks:Fine Chemical
Company Name: Hebei shuoxi biotechnology co. LTD
Tel: +8613081092107
Products Intro: Product Name:Pyrrolidine
Purity:99.9% Package:1KG;USD
Company Name: Hebei Xibaijie Biotechnology Co., Ltd.
Tel: 0086 15232103582
Products Intro: Product Name:pyrrolidine
Purity:99.7% Package:1KG;0USD
Company Name: Shijiazhuang Suking Biotechnology Co .,Ltd.
Tel: 18732196011
Products Intro: Product Name:pyrrolidine
Purity:Above 99% Package:1000ASSAYS;100USD
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:Tetrahydro pyrrole
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg

Lastest Price from Pyrrolidine manufacturers

  • Pyrrole, tetrahydro-
  • US $36.00 / KG/Tin
  • 2020-09-18
  • CAS:123-75-1
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 10tons
  • Pyrrolidine liquid
  • US $65.00 / KG
  • 2020-08-25
  • CAS:123-75-1
  • Min. Order: 1KG
  • Purity: 99%min
  • Supply Ability: 5000 Kilogram/Kilograms per Month
  • Pyrrolidine liquid
  • US $65.00 / KG
  • 2020-08-25
  • CAS:123-75-1
  • Min. Order: 1KG
  • Purity: 99%min
  • Supply Ability: 5000 Kilogram/Kilograms per Month

Related articles

  • What is Pyrrolidine?
  • Pyrrolidine, one of biogenic volatile amines, possesses nicotine-like synaptotropic actions on the nervous systems. Pyrrolidin....
  • Feb 20,2020
Pyrrolidine Basic information
Chemical Properties Production Pyrrolidine Chemical Properties Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage Characteristics Extinguishing agent Occupational standards
Product Name:Pyrrolidine
Product Categories:Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Pyrrolidines;Aliphatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Flavor
Mol File:123-75-1.mol
Pyrrolidine Structure
Pyrrolidine Chemical Properties
Melting point -63 °C
Boiling point 87-88 °C(lit.)
density 0.866
vapor density 2.45 (vs air)
vapor pressure 128 mm Hg ( 39 °C)
refractive index n20/D 1.443(lit.)
Fp 37 °F
storage temp. Flammables area
solubility water: miscible
form Liquid
pka11.27(at 25℃)
PH12.9 (100g/l, H2O, 20℃)
explosive limit1.6-10.6%(V)
Water Solubility Miscible with alcohol, ether, chloroform and water.
Sensitive Air Sensitive
JECFA Number1609
Merck 14,8015
BRN 102395
Stability:Stable; flammable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference123-75-1(CAS DataBase Reference)
NIST Chemistry ReferencePyrrolidine(123-75-1)
EPA Substance Registry SystemPyrrolidine (123-75-1)
Safety Information
Hazard Codes F,T,C
Risk Statements 11-22-23-34-35-20/21/22-20/22-R35-R20/21/22-R11
Safety Statements 16-26-36/37/39-45-33-S45-S36/37/39-S26-S16
RIDADR UN 1922 3/PG 2
WGK Germany 2
RTECS UX9650000
Autoignition Temperature653 °F
HS Code 2933 99 80
HazardClass 3
PackingGroup II
Hazardous Substances Data123-75-1(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 433 mg/kg
MSDS Information
SigmaAldrich English
ACROS English
ALFA English
Pyrrolidine Usage And Synthesis
Chemical Properties

Pyrrolidine appears as a colorless to pale yellow liquid with an ammonia-like odor. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.
Pyrrolidine is a cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family. It is a saturated organic heteromonocyclic parent, a member of pyrrolidines and an azacycloalkane. It is a conjugate base of a pyrrolidinium ion.

ProductionPyrrolidine can be produced from butanediol and ammonia, e.g., over an aluminum thorium oxide catalyst at 300℃ or over a nickel catalyst at 200℃ and 20 MPa under hydrogenation conditions. It can also be produced from tetrahydrofuran and ammonia over aluminum oxide at 275-375℃.Production can be obtained by reaction of 1,4-dihydroxyalkanes with amines in the presence of dehydrating agents at elevated temperatures or by reaction of primary amines with 1,4-dihaloalkanes. The dry distillation of 1,4-butanediamine dihydrochloride also generates pyrrolidine.
PyrrolidinePyrrolidine is also known as tetrahydro pyrrole, and it is colorless to pale yellow liquid with a pungent ammonia odor, smoke in air, and toxic. The relative density is 0.8618, the boiling point is 88~89℃, refractive index is 1.4402 (28℃). It is strong alkaline, miscible with water, soluble in alcohol, ether and chloroform.
Pyrrole can synthesize pyrrolidine by catalytic hydrogenation, pyrrolidine present in tobacco and carrot leaves, and it is natural substances, the molecular structure of pyrrolidine is cyclic secondary amine, which is generally the same with the reaction of amine. Pyrrolidine is an important organic chemical raw material, it can be used for drug preparation, fungicides and insecticides.
1. 1,4-butanediol as the raw material, dehydrate to tetrahydrofuran, and then reacte with ammonia, then pyrrolidine can be obtained.
2. Furan as raw material, react with ammonia in the catalyst at 400℃ can obtain tetrahydro pyrrole.
3. The 1,4-dichloro-butane as raw material, react with ammonia, pyrrolidine can be obtained.
4. Pyrrole as raw material, with the catalyst of rhodium or ruthenium, with the reaction of reduction can obtain .
The above information is edited by the chemicalbook of Wang Xiaodong.
Chemical PropertiesIt is colorless, transparent liquid with special smell. When exposed to light or moist air, it can turn yellow. It can be soluble in water, ethanol. It is corrosive and flammable. Boiling point is 87.0~89.0℃.
UsesPharmaceutical raw materials, organic synthesis, special organic solvents.
It can be used for the preparation of drugs, fungicides, insecticides, etc.
CategoryFlammable liquid.
Toxicity gradingHighly toxic.
Acute toxicityOral-rat LD50: 300 mg/kg; Oral-Mouse LD50: 450 mg/kg.
Flammability hazard characteristicsWhen exposed to fire, high temperature, oxidant, it is flammable; when heat, toxic nitric oxide gas can produce.
Storage CharacteristicsTreasury ventilation low-temperature drying; oxidants, acids stored separately.
Extinguishing agentDry, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Occupational standardsSTEL 0.1 mg /m.
Chemical Propertiescolourless to pale yellow liquid with a penetrating
Chemical PropertiesPyrrolidine has a penetrating amine-type odor, reminiscent of ammonia and piperidine. It is nauseating and diffusive
OccurrenceReported found in beer, bread, wheat bread, salmon caviar, fish, milk, leaves and stalks of celery, Camembert cheese, Limburger cheese, Russian cheeses, tilsit cheese, other cheeses, caviar, raw fatty fish, beer, Finnish whiskey, white wine, red wine, coffee, radish, malt, roasted peanut, sweet corn and roasted barley.
UsesPyrrolidine is a flammable alkaline liquid that undergoes reactions typical of secondary amines. It is used to prepare pesticides and rubber accelerators and as a chemical intermediate (usually the hydrochloride form) in the pharmaceutical industry. There is relatively limited industrial exposure to this material.
UsesUses of this compound in any major scalehave not been made. It occurs in tobacco andcarrot leaves. It is formed by reduction ofpyrrole.
UsesA heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).
DefinitionChEBI: A cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family.
PreparationVia overall 5-endo-trig cyclizations of homoallylic tosylamides.
Definitionpyrrolidine: A saturated heterocycliccompound having one nitrogenatom in a five-membered ring,C4H9N; r.d. 0.87; m.p. –63°C b.p.87°C. It is found in certain plants andthe ring structure is present in manyalkaloids.
Aroma threshold valuesDetection: 20.2 ppm
Taste threshold valuesTaste characteristics at 50 ppm: ammonia and fishy, amine-like with seaweed and shellfish nuances.
General DescriptionA colorless to pale yellow liquid with an ammonia-like odor. Flash point 37°F. Density 0.85 g / cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.
Air & Water ReactionsHighly flammable. Very soluble in water.
Reactivity ProfileTetrahydro pyrrole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of Tetrahydro pyrrole, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.
HazardFlammable, dangerous fire risk. Toxic by ingestion and inhalation.
Health HazardMay cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Health HazardThe acute toxicity of pyrrolidine is moderateon test animals. It is somewhat less toxicthan pyrrole. The vapors are an irritant tothe eyes and respiratory tract. The liquid iscorrosive to the skin. Contact with the eyescan cause damage. The oral LD50 value inrats is 300 mg/kg, while the inhalation LC50value in mice is 1300 mg/m3/2 h (NIOSH1986).
Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety ProfilePoison by ingestion and intravenous routes. Moderately toxic by inhalation. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx.
Purification MethodsDry pyrrolidine with BaO or sodium, then fractionally distil it, under N2, through a Todd column (p 11) packed with glass helices. [Beilstein 20 H 159, 20 I 36, 20 II 79, 20 III/IV 2072, 20/1 V 162.]
Tag:Pyrrolidine(123-75-1) Related Product Information
1-(TRIMETHYLSILYL)PYRROLIDINE 1-Methyl-2-pyrrolidineethanol N-NITROSOPYRROLIDINE 2-(2-Aminoethyl)-1-methylpyrrolidine 1-Pyrrolidino-1-cyclopentene N-[2-(4-Bromophenoxy)ethyl]pyrrolidine 3-PYRROLIDINO-1,2-PROPANEDIOL 1-AMINOPYRROLIDINE 1-Methyl-3-pyrrolidinol 3-CARBAMOYL-PROXYL 1-Cyanopyrrolidine 1-FORMYLPYRROLIDINE 1-Pyrrolidino-1-cyclohexene 3-Carboxy-2,2,5,5-tetraMethylpyrrolidine 1-Oxyl Free Radical 1-(3,4-DIHYDRO-2-NAPHTHYL)PYRROLIDINE 1-ETHYL-3-PYRROLIDINOL Pyrrolidine 1-Methylpyrrolidine