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| | 2-bromo-5-nitrobenzaldehyde Basic information |
| Product Name: | 2-bromo-5-nitrobenzaldehyde | | Synonyms: | 2-bromo-5-nitrobenzaldehyde;2-Bromo-5-nitrobenzenecarbaldehyde;4-Bromo-3-formylnitrobenzene;2-Bromo-5-nitrobenzadehyde;Benzaldehyde, 2-bromo-5-nitro- | | CAS: | 84459-32-5 | | MF: | C7H4BrNO3 | | MW: | 230.02 | | EINECS: | 200-002-4 | | Product Categories: | | | Mol File: | 84459-32-5.mol |  |
| | 2-bromo-5-nitrobenzaldehyde Chemical Properties |
| Melting point | 105-107 °C | | Boiling point | 307.2±27.0 °C(Predicted) | | density | 1.781 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | color | White to off-white |
| HazardClass | IRRITANT | | HS Code | 2913000090 |
| | 2-bromo-5-nitrobenzaldehyde Usage And Synthesis |
| Uses | 2-Bromo-5-nitrobenzaldehyde is a cholesteryl ester transfer protein (CETP) inhibitor. 2-Bromo-5-nitrobenzaldehyde is a commonly used reactant for the synthesis of (-)-Linarinic acid derivatives as neuroprotective agents against oxygen glucose deprivation (OGD)-induced cell damage. | | Synthesis | 2-Bromobenzaldehyde (10.0 g, 53.7 mmol) was dissolved in concentrated sulfuric acid (100 mL) at 0 °C. Potassium nitrate (5.43 g, 53.7 mmol) was added in batches over 1 h at this temperature. After addition, the reaction mixture was continued to be stirred for 40 min, followed by the addition of potassium nitrate (0.72 g). The reaction temperature was maintained at 0°C and stirring was continued for 3 hours. After completion of the reaction, the mixture was slowly poured into ice water. The precipitate precipitated was collected by filtration, washed well with water and finally recrystallized with ethyl acetate/pentane mixed solvent to give 2-bromo-5-nitrobenzaldehyde (11.7 g, 94% yield) as a white solid. The mass spectrometry (ESI) analysis was consistent with the theoretical value of C7H4BrNO3 (228.9). | | References | [1] Patent: WO2014/186313, 2014, A1. Location in patent: Page/Page column 173-174
[2] Patent: US2015/152108, 2015, A1. Location in patent: Paragraph 0881; 0882
[3] Tetrahedron Letters, 2016, vol. 57, # 1, p. 11 - 14
[4] Organic and Biomolecular Chemistry, 2017, vol. 15, # 6, p. 1355 - 1362
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5051 - 5057 |
| | 2-bromo-5-nitrobenzaldehyde Preparation Products And Raw materials |
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