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| | 17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one Basic information |
| Product Name: | 17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one | | Synonyms: | 17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one;Ethynyl trienolone;norgestrienone;(17R)-17-Hydroxy-19-norpregna-4,9,11-trien-20-yn-3-one;Ogyline;R-2010;RU-2010;19-Norpregna-4,9,11-trien-20-yn-3-one, 17-hydroxy-, (17α)- | | CAS: | 848-21-5 | | MF: | C20H22O2 | | MW: | 294.39 | | EINECS: | 212-698-6 | | Product Categories: | | | Mol File: | 848-21-5.mol |  |
| | 17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one Chemical Properties |
| Melting point | 169° | | alpha | D20 +63° (c = 0.5 in alc) | | Boiling point | 376.15°C (rough estimate) | | density | 1.1129 (rough estimate) | | refractive index | 1.4800 (estimate) | | pka | 12.76±0.40(Predicted) | | color | Pale-yellow needles from diisopropyl ether |
| | 17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one Usage And Synthesis |
| Uses | Norgestrienone is a progestin receptor agonist. Norgestrienone is commonly used as a progesterone compound in birth control pills and can be combined with ethinylestradiol. Norgestrienone is a click chemical. It contains Alkyne groups and can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Azide groups. Norgestrienone can be used in the study of hereditary angioneurotic edema[1][2]. | | Definition | ChEBI: Norgestrienone is a steroid. It has a role as an estrogen. | | Safety Profile | Human female reproductiveeffects by implant and intravaginal routes: changes inmenstrual cycle and fertility. When heated todecomposition it emits acrid smoke and irritating fumes | | References | [1] S Diaz, et al. Diaz S, Pavez M, Quinteros E, Diaz J, Robertson DN, Croxatto HB. Clinical trial with subdermal implants containing norgestrienone. Contraception. 1978 Oct;18(4):429-40. DOI:10.1016/0010-7824(78)90027-6
[2] Wu X, et al. Gestrinone combined with ultrasound-guided aspiration and ethanol injection for treatment of chocolate cyst of ovary. J Obstet Gynaecol Res. 2015 May;41(5):712-6. DOI:10.1111/jog.12612 |
| | 17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one Preparation Products And Raw materials |
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