(+)-沙利度胺
| 中文名称 | (+)-沙利度胺 |
|---|---|
| 中文同义词 | 酞咪呱啶酮(反应停);(+)-沙利度胺;(R)-(+)-THALIDOMIDE[干冰运输];(R)-(+)-萨力多胺 |
| 英文名称 | (R)-(+)-THALIDOMIDE |
| 英文同义词 | (R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE;R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE;(R)-(+)-THALIDOMIDE;6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2;6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid;(+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione;(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide;(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione |
| CAS号 | 2614-06-4 |
| 分子式 | C13H10N2O4 |
| 分子量 | 258.23 |
| EINECS号 | |
| 相关类别 | Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 2614-06-4.mol |
| 结构式 |  |
(+)-沙利度胺 性质
| 熔点 | 269-271°C |
|---|---|
| 沸点 | 401.48°C (rough estimate) |
| 密度 | 1.2944 (rough estimate) |
| 折射率 | 1.5300 (estimate) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.70±0.40(Predicted) |
| 颜色 | 白色 |
The transport of the (R)-Thalidomide from the R-imprinted MIP-1 through the donor phase to the receiver phase is much less owing to the stronger retention of the thalidomide in the organic phase. With the affinity of (R)-Thalidomide by the MIP present surface capture, that is more strongly than the other forms. In the case of (R)-Thalidomide, it is found to bind to the selective sites of the MIP more strongly than the other which reflects their different biological entities.
The (S)-Thalidomide imprints MIP nanoparticles exerted a greater cytotoxic effect on the caco-2 cells than the (R)-Thalidomide imprinted MIPs.
Adult female F344 rats are implanted with 9L gliosarcoma tumours intracranially, subcutaneously (flank), or both. Effectiveness of oral thalidomide alone, and with intraperitoneal BCNU or cisplatin combination chemotherapy, is assessed after several weeks treatment. Both serum and tissue concentrations of (R)-thalidomide are 40-50% greater than those of (S)-thalidomide. Co-administration of BCNU or cisplatin with thalidomide did not alter the concentration enantioselectivity.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 61-22 |
| 安全说明 | 53-36/37/39-45 |
| WGK Germany | 3 |
| RTECS号 | TI4925000 |
| 提供商 | 语言 |
|---|---|
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英文
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