(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷-9-甲酰胺 基本信息
| 中文名称 | (4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷-9-甲酰胺 |
|---|---|
| 中文同义词 | 度鲁特韦中间体4;德罗特韦 N-1;(4R,12AS)-N-[(2,4-二氟苯基)甲基]-3,4,6,8,12,12A-六氢-4-甲基-6,8-二氧代-7-(苯基甲氧基)-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3]恶嗪-9-甲酰胺;(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷-9-甲酰胺;(4R,12AS)-N-[(2,4-二氟苯基)甲基]-3,4,6,8,12,12A-六氢-4-甲基-6,8-二氧代-7-(苯基甲氧基)-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3];(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷;(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3]F嗪烷-9-甲酰胺;(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 嗪烷-9-甲酰胺 |
| 英文名称 | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide |
| 英文同义词 | (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide;(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;Dolutegravir Intermediate4;(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethox;SCHEMBL2302444;3 4 6-TRICHLOROBENZYL ALCOHOL 97 |
| CAS号 | 1206102-11-5 |
| 分子式 | C27H25F2N3O5 |
| 分子量 | 509.5 |
| EINECS号 | |
| 相关类别 | 原料药中间体;Dolutegravir INTERMEDIATES |
| Mol文件 | 1206102-11-5.mol |
| 结构式 | ![(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷-9-甲酰胺 结构式](CAS/20150408/GIF/1206102-11-5.gif) |
(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷-9-甲酰胺 性质
| 沸点 | 761.7±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 酸度系数(pKa) | 10.67±0.40(Predicted) |
安全信息
(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷-9-甲酰胺 上下游产品信息
上游原料
(S)-7-苯氧基-6,8-二氧-3,4,6,8,12,12A-六氢-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷-9-甲酸甲酯METHYL 4-(BENZYLOXY)-3-OXOBUTANOATE德罗特韦中间体5-[[[(2,4-二氟苯基)甲基]氨基]羰基]-1-(2-氧代乙基)-4-氧代-3-苄氧基-1,4-二氢-2-吡啶羧酸甲酯3-(苄氧基)-4-氧基-4H-吡喃-2-甲醛2,4-二氟苄胺度鲁特韦中间体-61-(2,2-二甲氧基乙基)-3-(苄氧基)-4-氧代-1,4-二氢吡啶-2,5-二羧酸二甲酯(R)-3-氨基丁醇4-氧代-3-苄氧基-4H-吡喃-2,5-二甲酸二甲酯1206102-04-6(4R,12AS)-7-苄氧基-4-甲基-6,8-二氧代-3,4,6,8,12,12A-六氢-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3]恶嗪-9-羧酸3-(苄氧基)-2-甲基-4H-吡喃-4-酮甲基麦芽酚