| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:MMP-2 Inhibitor I
CAS:10335-69-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:OLEYLHYDROXAMIC ACID
CAS:10335-69-0
Purity:98% Package:5mg; 10mg Remarks:Medbio
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| Company Name: |
Hubei Qifei Pharmaceutical Chemical Co., Ltd
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| Tel: |
027-027-59322506 18071128681 |
| Email: |
1438082200@qq.com |
| Products Intro: |
Product Name:OLEYLHYDROXAMICACID
CAS:10335-69-0
Purity:99% HPLC Package:25KG;200KG;5KG;1KG;1T
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| | OLEYLHYDROXAMIC ACID Basic information |
| Product Name: | OLEYLHYDROXAMIC ACID | | Synonyms: | OLEYLHYDROXAMIC ACID;N-hydroxyoleamide;(9Z)-9-Octadecenehydroxamic acid;(Z)-N-Hydroxy-9-octadecenamide;Hydroxamate derivative of oleic acid;N-Hydroxyoleic amide;Oleoylhydroxamic acid;9-Octadecenamide, N-hydroxy-, (9Z)- | | CAS: | 10335-69-0 | | MF: | C18H35NO2 | | MW: | 297.48 | | EINECS: | 2337284 | | Product Categories: | | | Mol File: | 10335-69-0.mol |  |
| | OLEYLHYDROXAMIC ACID Chemical Properties |
| Melting point | 61 °C | | density | 0.921±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 9.48±0.20(Predicted) | | EPA Substance Registry System | N-Hydroxyoleylamide (10335-69-0) |
| | OLEYLHYDROXAMIC ACID Usage And Synthesis |
| Biological Activity | mmp-2 inhibitor i, a hydroxamate-based, long-chain fatty acid, is a reversible inhibitor of matrix metalloproteinase (mmp)-2.matrix metalloproteinases (mmps) have been involved in the degradation of extracellular matrix. mmps contribute to long-term remodeling processes such as embryogenesis, tumor invasion, inflammation, angiogenesis, and wound healing. mmp-2, also known as gelatinase a or type iv collagenase, has been involved in regulating diverse cellular functions independent of its action on the extracellular matrix, including vascular tone, platelet aggregation, and mediation of the acute mechanical dysfunction of the heart immediately after ischemia and reperfusion [2]. up-regulation of mmp-2 has been associated with tumor invasion and metastasis [3].mmp-2 inhibitor i inhibited the activity of matrix metalloproteinase (mmp)-2 with the ki value of 1.6 μm [1]. mmp-2 inhibitor i attenuated cancer cell migration [3]. mmp-2 inhibitor i had also been used to preserve blood-brain barrier function in a wistar rat model of pneumococcal meningitis [4]. | | references | [1] berton a, rigot v, huet e, et al. involvement of fibronectin type ii repeats in the efficient inhibition of gelatinases a and b by long-chain unsaturated fatty acids[j]. journal of biological chemistry, 2001, 276(23): 20458-20465.
[2] wang w, schulze c j, suarez-pinzon w l, et al. intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury[j]. circulation, 2002, 106(12): 1543-1549.
[3] emmert-buck m r, roth m j, zhuang z, et al. increased gelatinase a (mmp-2) and cathepsin b activity in invasive tumor regions of human colon cancer samples[j]. the american journal of pathology, 1994, 145(6): 1285.
[4] barichello t, generoso j s, michelon c m, et al. inhibition of matrix metalloproteinases-2 and-9 prevents cognitive impairment induced by pneumococcal meningitis in wistar rats[j]. experimental biology and medicine, 2014, 239(2): 225-231. |
| | OLEYLHYDROXAMIC ACID Preparation Products And Raw materials |
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