醋酸缩宫素
| 中文名称 | 醋酸缩宫素 |
|---|---|
| 中文同义词 | 羟可待酮鉴别;醋酸缩宫素;羟可待酮鉴别 USP标准品;OXYTOCIN|醋酸催产素;(S)-N-((S)-1-((2-氨基-2-氧代乙基)氨基)-4-甲基-1-氧代戊烷-2-基)-1-((4R,7S,10S,13S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-13-((S)-仲丁基)-16-(4-氧基苯基)-6,9,12,15,18-五氧代-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羰基)吡咯烷-2-甲酰胺乙酸盐;醋酸催产素,10 MM DMSO 溶液;OXYTOCIN ACETATE|CAS 6233-83-6;6233-83-6;Oxytocin acetate |
| 英文名称 | Oxytocin acetate |
| 英文同义词 | Oxytocin Identification (15 mg) (COLD SHIPMENT REQUIRED);Orasthin Acetate;Oxytocin Monoacetate;Perlacton Acetate;Pitocin Acetate;Synpitan Acetate;Syntocinon Acetate;Uteracon Acetate |
| CAS号 | 6233-83-6 |
| 分子式 | C43H66N12O12S2.C2H4O2 |
| 分子量 | 1067.24 |
| EINECS号 | 228-347-5 |
| 相关类别 | 原料药;药物多肽;原料药;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 6233-83-6.mol |
| 结构式 |  |
醋酸缩宫素 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO:44.0(最大浓度 mg/mL);41.23(最大浓度 mM) 水:50.0(最大浓度 mg/mL);46.85(最大浓度 mM) |
| 形态 | 结晶固体 |
| 颜色 | 白色至米白色 |
| 序列 | Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6) |
| InChIKey | DSZOEVVLZMNAEH-SIVBSZNNNA-N |
Oxytocin acetate 是一种多效的下丘脑肽 (hypothalamic peptide)，有助于分娩、哺乳和亲社会行为。Oxytocin acetate 可以作为一种压力应对分子，具有抗炎、抗氧化剂和保护作用，特别是在面对逆境或创伤时。
纯度 (HPLC) ≥98.0%
醋酸根含量(HPLC): 6.0%～10.0%
水分含量(Karl Fischer) ≤8.0%
During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only.Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s).
| Animal Model: | Fifty-six male Lister-hooded rats (150–200 g) |
| Dosage: | 0.1 mg/kg-0.3 mg/kg |
| Administration: | Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose |
| Result: | Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group. |
多肽
醋酸缩宫素是一种肽类激素。催产素由垂体后叶分泌。由下丘脑室旁核和视上核合成。醋酸缩宫素由9个氨基酸组成和醋酸。生理作用：刺激乳腺分泌乳汁，在分娩过程中促进子宫平滑肌的收缩。此外，它还能减少人体内肾上腺酮等压力激素的水平，以降低血压。参考质量标准
外观:白色粉末纯度 (HPLC) ≥98.0%
醋酸根含量(HPLC): 6.0%～10.0%
水分含量(Karl Fischer) ≤8.0%
安全信息
| 危险品运输编号 | UN 2811 6.1 / PGII |
|---|---|
| 海关编码 | 2937190000 |