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Sorbic acid

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Products Intro: Product Name:Sorbic acid
CAS:22500-92-1
Purity:98% Package:10g;50g;100g;250g;500g
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Sorbic acid Basic information
Product Name:Sorbic acid
Synonyms:
CAS:22500-92-1
MF:C6H8O2
MW:0
EINECS:
Product Categories:
Mol File:22500-92-1.mol
Sorbic acid Structure
Sorbic acid Chemical Properties
solubility Slightly soluble in water, freely soluble in ethanol (96 per cent).
Safety Information
MSDS Information
Sorbic acid Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder.
Chemical PropertiesSorbic acid is a tasteless, white to yellow-white crystalline powder with a faint characteristic odor.
UsesPharmaceutic aid (antimicrobial agent).
DefinitionChEBI: A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring.
Production MethodsNaturally occurring sorbic acid may be extracted as the lactone (parasorbic acid) from the berries of the mountain ash Sorbus aucuparia L. (Fam. Rosaceae). Synthetically, sorbic acid may be prepared by the condensation of crotonaldehyde and ketene in the presence of boron trifluoride; by the condensation of crotonaldehyde and malonic acid in pyridine solution; or from 1,1,3,5- tetraalkoxyhexane. Fermentation of sorbaldehyde or sorbitol with bacteria in a culture medium has also been used.
Pharmaceutical ApplicationsSorbic acid is an antimicrobial preservative with antibacterial and antifungal properties used in pharmaceuticals, foods, enteral preparations, and cosmetics. Generally, it is used at concentrations of 0.05–0.2% in oral and topical pharmaceutical formulations, especially those containing nonionic surfactants. Sorbic acid is also used with proteins, enzymes, gelatin, and vegetable gums. It has been shown to be an effective preservative for promethazine hydrochloride solutions in a concentration of 1 g/L.
Sorbic acid has limited stability and activity against bacteria and is thus frequently used in combination with other antimicrobial preservatives or glycols, when synergistic effects appear to occur.
SafetySorbic acid is used as an antimicrobial preservative in oral and topical pharmaceutical formulations and is generally regarded as a nontoxic material. However, adverse reactions to sorbic acid and potassium sorbate, including irritant skin reactions and allergic hypersensitivity skin reactions (which are less frequent), have been reported.
Other adverse reactions that have been reported include exfoliative dermatitis due to ointments that contain sorbic acid, and allergic conjunctivitis caused by contact lens solutions preserved with sorbic acid.
No adverse reactions have been described after systemic administration of sorbic acid, and it has been reported that it can be ingested safely by patients who are allergic to sorbic acid. However, perioral contact urticaria has been reported.
The WHO has set an estimated total acceptable daily intake for sorbic acid, calcium sorbate, potassium sorbate, and sodium sorbate, expressed as sorbic acid, at up to 25 mg/kg bodyweight. Animal toxicological studies have shown no mammalian carcinogenicity or teratogenicity for sorbic acid consumed at up to 10% of the diet.
LD50 (mouse, IP): 2.82 g/kg
LD50 (mouse, oral): 3.20 g/kg
LD50 (mouse, SC): 2.82 g/kg
LD50 (rat, oral): 7.36 g/kg
storageSorbic acid is sensitive to oxidation, particularly in the presence of light; oxidation occurs more readily in aqueous solution than in the solid form. Sorbic acid may be stabilized by phenolic antioxidants such as 0.02% propyl gallate.
Sorbic acid is combustible when exposed to heat or flame. When heated to decomposition, it emits acrid smoke and irritating fumes. The bulk material should be stored in a well-closed container, protected from light, at a temperature not exceeding 40℃.
IncompatibilitiesSorbic acid is incompatible with bases, oxidizing agents, and reducing agents. Some loss of antimicrobial activity occurs in the presence of nonionic surfactants and plastics. Oxidation is catalyzed by heavy-metal salts. Sorbic acid will also react with sulfur-containing amino acids, although this can be prevented by the addition of ascorbic acid, propyl gallate, or butylhydroxytoluene.
When stored in glass containers, the solution becomes very pH sensitive; therefore, preparations using sorbic acid as a preservative should be tested for their microbial purity after prolonged periods of storage.
Aqueous solutions of sorbic acid without the addition of antioxidants are rapidly decomposed when stored in polypropylene, polyvinylchloride, and polyethylene containers.
Regulatory StatusGRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (ophthalmic solutions; oral capsules, solutions, syrups, tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sorbic acid Preparation Products And Raw materials
Tag:Sorbic acid(22500-92-1) Related Product Information
Potassium sorbate Calcium sorbate Sodium Sorbate