Azelastine NEW

Specification of Azelastine CAS 58581-89-8:

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Azelastine is a potent, second-generation antihistamine with additional anti-inflammatory properties. It is primarily used to treat allergic conditions affecting the eyes and nasal passages.

Chemical & Pharmacological Profile:

Class: Phthalazinone derivative

Mechanism: Blocks histamine H₁ receptors and inhibits the release of inflammatory mediators (e.g., leukotrienes, serotonin, platelet-activating factor).

Formulations: Available as nasal spray, ophthalmic (eye) drops, and occasionally oral tablets (less common).

Onset of Action: Rapid—within 15–30 minutes for nasal and ocular forms.

Main Medical Uses:

Allergic Rhinitis (Seasonal & Perennial)

Azelastine nasal spray reduces symptoms like sneezing, runny nose, itching, and congestion.

Allergic Conjunctivitis

Eye drops relieve redness, itching, and watering caused by allergens (e.g., pollen, dust).

Vasomotor Rhinitis (Non-allergic rhinitis)

Effective in reducing nasal symptoms not caused by allergies, thanks to its anti-inflammatory effects.

Adjunct in Asthma or Chronic Cough (Off-label, limited use)

Occasionally used when upper airway inflammation contributes to symptoms.

Advantages:

Dual action: antihistaminic + mast cell stabilizing

Local administration minimizes systemic side effects

Generally well-tolerated; common side effect is mild bitter taste (nasal spray) or transient stinging (eye drops)

Azelastine is valued for its fast relief and effectiveness in managing both allergic and non-allergic upper airway conditions.

Package of Azelastine CAS 58581-89-8:

Application of Azelastine CAS 58581-89-8:

Used for the treatment of bronchial asthma and nasal allergies.