Mosapride citrate NEW

Mosapride citrate is the citrate salt of mosapride, a selective 5-HT₄ (serotonin) receptor agonist used clinically as a gastroprokinetic agent to enhance gastric motility. Chemically, it is a benzamide derivative.

Pharmaceutical vs. Chemical Grade

• Pharmaceutical Grade: Formulated into tablets for treating functional dyspepsia, gastroesophageal reflux disease (GERD), and gastroparesis.

  Chemical/Research Grade: A high-purity (typically ≥98%), solid powder with a defined chemical structure (CAS: 112885-42-4), sold for non-therapeutic laboratory use.

Primary Uses in Chemical and Research Grades

As a research chemical, it serves as a selective pharmacological tool:

1. Biochemical & Pharmacological Research:

• Selective 5-HT₄ Receptor Agonist: Used in in vitro assays (e.g., cell lines expressing 5-HT₄ receptors) and in vivo animal models to study the specific role of 5-HT₄ receptor signaling in gastrointestinal motility, visceral sensitivity, and neurotransmitter release.

  Mechanism Studies: A tool to investigate downstream pathways of 5-HT₄ activation and compare efficacy/selectivity against other prokinetic agents (e.g., metoclopramide).

2. Analytical Reference Standard:

• Primary Standard: Used in HPLC, LC-MS/MS, and other analytical methods for quantitative analysis, quality control, and method validation during pharmaceutical manufacturing of mosapride products.

  Bioanalytical Applications: Essential for developing assays to measure mosapride concentration in biological samples (plasma, tissue) for pharmacokinetic and metabolism studies.

3. Metabolic and Toxicology Studies:

• Used to identify and characterize its metabolites (primarily via CYP3A4 metabolism) and to assess preclinical safety profiles in controlled research settings.

Key Distinction for Handling

• Not for Human Use: Strictly for laboratory research.

  Handling & Storage: Store in a cool, dry place. Handle using standard laboratory safety practices; avoid inhalation or direct contact.

  Solubility: Soluble in DMSO and methanol, slightly soluble in water, which informs its preparation for in vitro studies.

Summary

In essence, chemical-grade mosapride citrate is a selective receptor agonist used as a precise tool for gastrointestinal pharmacology research, analytical chemistry, and drug metabolism studies.

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