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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antiviral drugs>Efavirenz
Efavirenz
  • Efavirenz
  • Efavirenz
  • Efavirenz
  • Efavirenz
  • Efavirenz

Efavirenz

Price Get Latest Price
Package 1Kg/Bag 25Kg/Bag 100Kg/Bag
Min. Order: 0.1Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-04-22

Product Details

Product Name: Efavirenz CAS No.: 154598-52-4
EC-No.: 620-492-6 Min. Order: 0.1Kg/Bag
Purity: USP Supply Ability: 20 tons
Release date: 2024/04/22

Product Information

Product NamePharmaceutical Intermediate CAS 154598-52-4 Efavirenz for Anti-Allergic 
Appearancepowder
cas154598-52-4
Assay90%
KeywordsEfavirenz; API Efavirenz powder;Efavirenz Medicine 
Shelf Life24 months when properly stored
StorageKeep in a cool, dry, dark location


Usage

What is Efavirenz ?

Efavirenz D5 (Sustiva)84 is also mandated for use with at leasttwo other antiretroviral agents. The compound is morethan 99% protein bound, and CSF concentrations exceedthe free fraction in the serum. Metabolism occurs in theliver. The half-life of a single dose of Efavirenz D5 is 52 to 76hours, and 40 to 55 after multiple doses (the drug inducesits own metabolism). Peak concentration is achieved in 3to 8 hours. Elimination is 14% to 34% in urine (as metabolites)and 16% to 41% in feces (primarily as Efavirenz D5).The oral dosage form is supplied as a capsule.

Function of Efavirenz

Efavirenz is one of the most commonly prescribed antiretroviral medications in the world. Several large randomized, controlled trials[RCTs] have demonstrated the superior ability of efavirenz to suppress the HIV virus when used as part of a 3-drug cocktail[2]. The introduction of Atripla in 2006 combined efavirenz and two other agents into a single pill, once-daily formulation. This formulation was more convenient and better tolerated than alternatives, and thus resulted in improved adherence to antiretroviral medications[3]. However, neuropsychiatric side effects associated with efavirenz have been reported to occur in 40-50% of patients and represent one of the limiting factors of this regime

Application of Efavirenz

For use in combination treatment of HIV infection (AIDS)


COA

Test items

Specification

Appearance

White to off-white crystalline powder

solubility

50mg/ml in Methanol Solvent,clear

Water

≤0.5%

Related substance

Impurity A ≤0.15%

Impurity B ≤0.40%

Impurity C ≤0.10%

Impurity D ≤0.10%

Impurity E ≤0.10%

Impurity I ≤0.25%

Impurity K ≤0.10%

Other unknown individual impurity ≤0.10%

Total impurities ≤0.10%

Isomeride

≤0.5%

Heavy Metal

≤20ppm

Residue on ignition

≤0.2%

Assay

Not less than 98%

Company Information

Article illustration



Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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