Antiviral drugs

At present, virus infection is the most prevalent disease in the world, about 60% of the infectious disease is caused by a virus, and new viruses have been found constantly, which is highly contagious and has high fatality rate, causing serious harm to human health. Antiviral therapy is the fundamental treatment of viral infectious diseases. For acute infection, antiviral therapy helps to reduce symptoms and shorten the course of treatment; and for chronic persistent infection is the treatment of the fundamental, such as AIDS, hepatitis B, hepatitis C and so on. Different viral infections cause different disorders and require different antiviral medications.
Although over the years the development of gene engineering and chemical synthesis of antiviral drugs for clinical use of drugs to control the virus infection and provide more choices and opportunities, and it has been confirmed to have clinical value of antiviral drugs is still one of the few, drug indications are very limited.
In particular, it is difficult to achieve a cure for some of the chronic viral infections. Because the virus is obligate intracellular parasites, its proliferation depends on biosynthesis of the host cell, some virus nucleic acid directly integrated into the host cell gene. Therefore, it is necessary to select antiviral drugs according to the characteristics of the virus. Antiviral drugs should selectively destroy or inhibit the virus inside and outside of the cell, while for normal cells, at least for non-infected cells do not produce lethal damage. Therefore, it is more difficult to make antiviral drugs that have an inhibitory effect on the intracellular virus, to achieve clinical antiviral effect, but not on the metabolism of the host cell. In addition, the better effect of antiviral drugs to protect uninfected cells and early infection cell that have not yet produced significant lesions, however, the symptoms of viral infectious diseases are lack of specificity, it is not easy to diagnose early, when the clinical symptoms appear of virus infection, the virus proliferation has reached a certain degree. For example, a large number of viruses have been infected and release in the cell proliferation When the prevalence of influenza and Japanese encephalitis, and the body is in viremia or viremia late stage, has caused tissue damage, then we should check with effective virus drugs, although it is possible to control the further proliferation and spread of the virus, but often "too late", has not played a decisive role in the treatment. Some virus-induced syndromes are common and relatively benign or self-limiting, so that only drugs with a high therapeutic index (ratio of efficacy to toxicity) can be accepted. So it is still very difficult task to develop safe and effective, selective, easy to use antiviral drugs.
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Structure Chemical Name CAS MF
Lopinavir Lopinavir 192725-17-0 C37H48N4O5
Maraviroc Maraviroc 376348-65-1 C29H41F2N5O
2-[(Acetyloxy)methoxy]ethyl acetate 2-[(Acetyloxy)methoxy]ethyl acetate 59278-00-1 C7H12O5
1,3-Diacetoxy-2-(acetoxymethoxy)propane 1,3-Diacetoxy-2-(acetoxymethoxy)propane 86357-13-3 C10H16O7
2,5,6-Triaminopyrimidin-4-ol sulphate 2,5,6-Triaminopyrimidin-4-ol sulphate 1603-02-7 C4H9N5O5S
Nevirapine Nevirapine 129618-40-2 C15H14N4O
Entecavir hydrate Entecavir hydrate 209216-23-9 C12H17N5O4
Tenofovir disoproxil fumarate Tenofovir disoproxil fumarate 202138-50-9 C23H34N5O14P
NELFINAVIR NELFINAVIR 159989-64-7 C32H45N3O4S
Tenofovir Tenofovir 147127-20-6 C9H14N5O4P
DELAVIRDINE DELAVIRDINE 136817-59-9 C22H28N6O3S
Abacavir sulfate Abacavir sulfate 188062-50-2 C28H38N12O6S
Acyclovir Acyclovir 59277-89-3 C8H11N5O3
Efavirenz Efavirenz 154598-52-4 C14H9ClF3NO2
(+)-5-Iodo-2'-deoxyuridine (+)-5-Iodo-2'-deoxyuridine 54-42-2 C9H11IN2O5
Adefovir dipivoxil Adefovir dipivoxil 142340-99-6 C20H32N5O8P
Trifluridine Trifluridine 70-00-8 C10H11F3N2O5
Emtricitabine Emtricitabine 143491-57-0 C8H10FN3O3S
Cidofovir Cidofovir 149394-66-1 C8H14N3O6P
Ritonavir Ritonavir 155213-67-5 C37H48N6O5S2
Famciclovir Famciclovir 104227-87-4 C14H19N5O4
Entecavir Entecavir 142217-69-4 C12H15N5O3
Dideoxyinosine Dideoxyinosine 69655-05-6 C10H12N4O3
Ribavirin Ribavirin 36791-04-5 C8H12N4O5
Tenofovir disoproxil Tenofovir disoproxil 201341-05-1 C19H30N5O10P
Rimantadine hydrochloride Rimantadine hydrochloride 1501-84-4 C12H22ClN
Lamivudine Lamivudine 134678-17-4 C8H11N3O3S
Tenofovir Alafenamide Fumarate Tenofovir Alafenamide Fumarate 1392275-56-7 2(C21H29N6O5P).C4H4O4
Zidovudine Zidovudine 30516-87-1 C10H13N5O5
OSELTAMIVIR OSELTAMIVIR 196618-13-0 C16H28N2O4
Raltegravir potassium Raltegravir potassium 871038-72-1 C20H20FN6O5.K
Saquinavir Saquinavir 127779-20-8 C38H50N6O5
Adefovir Adefovir 106941-25-7 C8H12N5O4P
PotassiuM sodiuM Dehydroandrographolide Succinate PotassiuM sodiuM Dehydroandrographolide Succinate
2'-Deoxy-L-thymidine 2'-Deoxy-L-thymidine 3424-98-4 C10H14N2O5
Atovaquone Atovaquone 95233-18-4 C22H19ClO3
Stavudine Stavudine 3056-17-5 C10H12N2O4
2'-Deoxycytidine 2'-Deoxycytidine 207121-53-7 C9H13N3O4
Vidarabine Vidarabine 5536-17-4 C10H13N5O4
pirodavir pirodavir 124436-59-5 C21H27N3O3
Arbidol hydrochloride Arbidol hydrochloride 131707-23-8 C22H26BrClN2O3S
Cidofovir Cidofovir 113852-37-2 C8H14N3O6P
Abacavir Abacavir 136470-78-5 C14H18N6O
(R)-(+)-9-(2-Hydroxypropyl)adenine (R)-(+)-9-(2-Hydroxypropyl)adenine 14047-28-0 C8H11N5O
Brivudine Brivudine 69304-47-8 C11H13BrN2O5
Raltegravir Raltegravir 518048-05-0 C20H21FN6O5
NETOBIMIN NETOBIMIN 88255-01-0 C14H20N4O7S2
Ganciclovir Ganciclovir 82410-32-0 C9H13N5O4
Tecovirimat Tecovirimat 816458-31-8 C19H15F3N2O3
Valacyclovir hydrochloride Valacyclovir hydrochloride 124832-27-5 C13H21ClN6O4
Ganciclovir sodium Ganciclovir sodium 107910-75-8 C9H12N5NaO4
PLECONARIL PLECONARIL 153168-05-9 C18H18F3N3O3
Asunaprevir Asunaprevir 630420-16-5 C35H46ClN5O9S
Exalamide Exalamide 53370-90-4 C13H19NO2
Clevudine Clevudine 163252-36-6 C10H13FN2O5
INTERFERON ALPHA RECOMBINANT RAT INTERFERON ALPHA RECOMBINANT RAT 307005-25-0
Dicacetyl-Aciclovir Dicacetyl-Aciclovir
Moroxydine hydrochloride Moroxydine hydrochloride 3160-91-6 C6H14ClN5O
Valaciclovir Valaciclovir 124832-26-4 C13H21ClN6O4
RIMANTADINE HCL USP(CRM STANDARD) RIMANTADINE HCL USP(CRM STANDARD)
2,4,6-Triiodoresorcinol 2,4,6-Triiodoresorcinol 19403-92-0 C6H3I3O2
Moroxydine Moroxydine 3731-59-7 C6H13N5O
Tilorone Tilorone 27591-97-5 C25H34N2O3
ABACAVIR SULFATE ABACAVIR SULFATE 136777-48-5 C28H38N12O6S
Aciclovir sodium Aciclovir sodium 69657-51-8 C8H10N5NaO3
Foscarnet sodium Foscarnet sodium 63585-09-1 CNa3O5P
Indinavir Indinavir 150378-17-9 C36H47N5O4
Tilorone dihydrochloride Tilorone dihydrochloride 27591-69-1 C25H36Cl2N2O3
Arbidol Arbidol 131707-25-0 C22H25BrN2O3S
FTIBAMZONE FTIBAMZONE 210165-00-7 C14H15N7O2S2
Penciclovir Penciclovir 39809-25-1 C10H15N5O3
Peramivir Peramivir 229614-55-5 C15H28N4O4
3-NITROSOBENZAMIDE 3-NITROSOBENZAMIDE 144189-66-2 C7H6N2O2
Indinavir sulfate Indinavir sulfate 157810-81-6 C36H49N5O8S
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