Clobetasol Propionate 25122-46-7

Clobetasol Propionate

Basic Information:

CAS: 25122-46-7
Molecular formula: C25H32ClFO5
Molecular weight: 466.97
EINECS: 246-634-3
Content: 98.5-102%
Density: 1.28 g/cm3
Melting Point: 195.5-197 °C
Boiling Point: 569 °C at 760 mmHg
Flash Point: 297.9 °C
Specific rotation: +98 - +104 °C
Packing: 1kg/aluminum foil bag
Appearance: white crystalline powder


COA:

Description:

Clobetasol Propionate is a derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

Clobetasol propionate is a corticosteroid of synthetic steroid used to treat various skin disorders including inflammation, itching, herpes labialis, eczema, psoriasis and lichen sclerosus. Clobetasol propionate is also highly effective for contact dermatitis caused by exposure to poison ivy/oak and auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). Clobetasol propionate is used as first-line treatment for both acute and chronic GVHD of the skin.


Application:

1, clobetasol propionate is a synthetic high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary vascular contraction, the anti-inflammatory effects of hydrocortisone is about 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. At the same time with inhibition of cell mitosis, can effectively penetrate into the skin stratum corneum.

2, external apply to chronic eczema, neurodermatitis, psoriasis and palmoplantar pustulosis, lichen planus, discoid lupus erythematosus, glucocorticoid, topical treatment of pruritic effective and non infectious inflammatory skin disease.

3, has the inhibitory effects of anti-inflammatory, anti allergic, anti proliferation, immune.Can compound products: ketoconazole. Miconazole nitrate, vitamin A acid cream and liniment.