Adrenal corticosteroids

Adrenal corticosteroid is the general term for adrenal cortex hormones, belonging to steroid compounds. It can be divided into three categories:
(1)  mineralocorticoid hormone secreted by Zona glomerulosa, including aldosterone and deoxycorticosterone and so on.
(2)  glucocorticoid, it is synthesized and secreted from the zona fasciculata, including hydrocortisone and cortisone, etc., its secretion and production are regulated by the adrenocorticotropic hormone (ACTH).
(3)  sex hormones, secreted by the zona reticularis, usually referred to adrenocortical hormones, excluding such kind of sex hormones.
Commonly used clinical adrenocortical hormones mainly refer to glucocorticoids. Under physiological conditions, the secretion of glucocorticoids mainly affects the metabolism of substances. Glucocorticoids beyond physiological dose have anti-inflammatory, anti-immune and other pharmacological effects.

ACTH is a kind of important hormones that maintain the normal adrenal gland and function. Its synthesis and secretion proceed inside the pituitary basophilic cells when the anterior pituitary is under the action of hypothalamus corticotropin-releasing hormone (CRH). Glucocorticoids play a long negative feedback effect on hypothalamus and anterior pituitary, inhibiting the secretion of CRH and ACTH. In physiological conditions, the hypothalamus, pituitary and adrenal gland are maintained in a relative dynamic balance with ACTH deficiency being able to cause adrenal cortical atrophy and its reduced secretion capability. The ACTH also has a short negative feedback regulation that controls its own release.

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Structure Chemical Name CAS MF
Fluticasone propionate Fluticasone propionate 80474-14-2 C25H31F3O5S
Dexamethasone Dexamethasone 50-02-2 C22H29FO5
Fluocinolone acetonide Fluocinolone acetonide 67-73-2 C24H30F2O6
11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 13951-70-7 C21H28O6
Hydrocortisone Hydrocortisone 50-23-7 C21H30O5
Ciclesonide Ciclesonide 141845-82-1 C32H45O7
Dexamethasone-17-acetate Dexamethasone-17-acetate 1177-87-3 C24H31FO6
Deflazacort Deflazacort 14484-47-0 C25H31NO6
Betamethasone Dipropionate EP?Impurity?A Betamethasone Dipropionate EP?Impurity?A 378-44-9 C22H29FO5
Prednisone Prednisone 53-03-2 C21H26O5
Hydrocortisone acetate Hydrocortisone acetate 50-03-3 C23H32O6
Betamethasone 17,21-dipropionate Betamethasone 17,21-dipropionate 5593-20-4 C28H37FO7
Triamcinolone acetonide Triamcinolone acetonide 76-25-5 C24H31FO6
Budesonide Budesonide 51333-22-3 C25H34O6
dl-threo-Ritalinic Acid Isopropyl Ester dl-threo-Ritalinic Acid Isopropyl Ester 93148-46-0 C16H23NO2
glucocorticoid hormone glucocorticoid hormone
Hydrocortisone Hydrocortisone 74050-20-7 C26H36O7
Dexamethasone 21-phosphate disodium salt Dexamethasone 21-phosphate disodium salt 2392-39-4 C22H28FNa2O8P
Diflorasone Diflorasone 2557-49-5 C22H28F2O5
Hydrocortisone sodium succinate Hydrocortisone sodium succinate 125-04-2 C25H33O8.Na
Mometasone furoate Mometasone furoate 83919-23-7 C32H32Cl2O8
Hydrocortisone-17-butyrate Hydrocortisone-17-butyrate 13609-67-1 C25H36O6
Betamethasone 17-valerate Betamethasone 17-valerate 2152-44-5 C27H37FO6
Betamethasone 21-acetate Betamethasone 21-acetate 987-24-6 C24H31FO6
Triamcinolone Triamcinolone 124-94-7 C21H27FO6
Hydrocortisone hemisuccinate hydrate Hydrocortisone hemisuccinate hydrate 83784-20-7 C25H36O9
Dexamethasone sodium phosphate Dexamethasone sodium phosphate 55203-24-2 C22H28FNa2O8P
Methylprednisolone Methylprednisolone 83-43-2 C22H30O5
Deoxycorticosterone acetate Deoxycorticosterone acetate 56-47-3 C23H32O4
Bevacizumab Bevacizumab 216974-75-3 C6638H10160N1720O2108S44
Prednisolone Prednisolone 50-24-8 C21H28O5
Fluocinonide Fluocinonide 356-12-7 C26H32F2O7
Desoxycorticosterone Desoxycorticosterone 64-85-7 C21H30O3
Beclomethasone dipropionate Beclomethasone dipropionate 5534-09-8 C28H37ClO7
Hydrocortisone 21-hemisuccinate Hydrocortisone 21-hemisuccinate 2203-97-6 C25H34O8
Betamethasone 21-phosphate disodium Betamethasone 21-phosphate disodium 151-73-5 C22H28FNa2O8P
Fluticasone Fluticasone 90566-53-3 C25H31F3O5S
Prednisone 21-acetate Prednisone 21-acetate 125-10-0 C23H28O6
Fludrocortisone acetate Fludrocortisone acetate 514-36-3 C23H31FO6
Meprednisone Meprednisone 1247-42-3 C22H28O5
(r)-budesonide (r)-budesonide 51372-29-3 C25H34O6
Clobetasol propionate Clobetasol propionate 25122-46-7 C25H32ClFO5
Methylprednisolone acetate Methylprednisolone acetate 53-36-1 C24H32O6
Isoflupredone Isoflupredone 338-95-4 C21H27FO5
Prednisolone phosphate sodium Prednisolone phosphate sodium 125-02-0 C21H27Na2O8P
Halometasone Halometasone 50629-82-8 C22H27ClF2O5
Flurandrenolide Flurandrenolide 1524-88-5 C24H33FO6
Halcinonide Halcinonide 3093-35-4 C24H32ClFO5
Prednisolone-21-acetate Prednisolone-21-acetate 52-21-1 C23H30O6
Cortisone acetate Cortisone acetate 50-04-4 C23H30O6
Fluorometholone Fluorometholone 426-13-1 C22H29FO4
Prednisolone sodium succinate Prednisolone sodium succinate 1715-33-9 C25H31O8.Na
Mometasone Mometasone 105102-22-5 C27H30Cl2O6
Triamcinolone acetonide 21-acetate Triamcinolone acetonide 21-acetate 3870-07-3 C26H33FO7
Hydrocortisone sodium phosphate Hydrocortisone sodium phosphate 6000-74-4 C21H29O8P.2Na
Fluocortolone Fluocortolone 152-97-6 C22H29FO4
Methylprednisolone Hemisuccinate Methylprednisolone Hemisuccinate
Fludrocortisone Fludrocortisone 127-31-1 C21H29FO5
cloprednol cloprednol 5251-34-3 C21H25ClO5
Clobetasol Clobetasol 25122-41-2 C22H28ClFO4
DexamethasoneAcefurate DexamethasoneAcefurate
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