Tetramethylpyrazine

Price	$100
Package	25KG

Product Details

Product Name: Tetramethylpyrazine	CAS No.: 1124-11-4
EC-No.: 214-391-2	Min. Order: 25KG
Purity: 98%	Supply Ability: 1000KG
Release date: 2019/07/06

CR171

Product Name:	Tetramethylpyrazine
Synonyms:	BS Factor;Ligustrazine;Pyrazine,tetramethyl-;Tetramethylpyrazin;tetramethyl-pyrazin;2,3,5,6-TETRAMETHYLPYRAZINE;2,3,5,6-TETRAMETHYLPYRAZINES;2,3,5,6-TETRAMETHYL-1,4-PYRAZINE
CAS:	1124-11-4
MF:	C8H12N2
MW:	136.19
EINECS:	214-391-2
Product Categories:	Pyrazine;Heterocyclic Compounds;Pyrazines;Mono- & Polyalkylpyrazines;pyrazine Flavor;Alphabetical Listings;Flavors and Fragrances;Q-Z;Certified Natural ProductsFlavors and Fragrances;Building Blocks;Heterocyclic Building Blocks;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File:	1124-11-4.mol

Tetramethylpyrazine Chemical Properties

Melting point	77-80 °C(lit.)
Boiling point	190 °C(lit.)
density	1.08
FEMA	3237
Fp	128-130°C/200mm
storage temp.	Store below +30°C.
solubility	4g/l
Water Solubility	Soluble in water (4 g/L at 20°C).
BRN	113100
Stability:	Stable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference	1124-11-4(CAS DataBase Reference)
NIST Chemistry Reference	Pyrazine, tetramethyl-(1124-11-4)
EPA Substance Registry System	Pyrazine, tetramethyl-(1124-11-4)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-37/38-41-36/37/38
Safety Statements	26-39-24/25-37/39-36
WGK Germany	3
RTECS	UQ3905000
TSCA	Yes
HS Code	29339990

MSDS Information

Provider	Language
Tetramethylpyrazine	English
ACROS	English
SigmaAldrich	English
ALFA	English

Tetramethylpyrazine Usage And Synthesis

Description	Tetramethylpyrazine (TMP) is a kind of alkaloids identified in Ligusticum wallichii FRANCH. It has various kinds of medical applications. It has long been used in China for the treatment of cardiovascular problems. It also has antiinflammatory and analgesic effect. It can be used for the treatment of diabetic peripheral neuropathy. Through effectively penetrating across the blood-brain barrier, it can exert its neuroprotection function which is useful for the treatment of ischemic brain injury. Moreover, it can eliminate superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.
Chemical Characteristic	White crystal or powder. With aroma of beef and heated lard and fermented soybean flavor. It smells chocolate flavor when diluted to 20mg/kg. Boiling point is 190℃. Melting point is between 84 and 86℃. Soluble in ethanol, most non-volatile oils and propylene glycol, slightly soluble in water. Natural products exist in guava, roast beef, cocoa, coffee, shrimp and so on.
Uses	Permissible edible flavors, mainly used to prepare meat, cocoa, peanut, nut, coffee, chocolate flavor and so on; For medicine production; Used as flavoring agents, sweeteners for alcoholic beverages, flavor and enriching supplement for cigarettes.
Preparation	Butanedione monoxime generated by butanone and ethyl nitrite condensation is reduced and cyclized to produce methylpyrazine. The cyclization reaction product is subjected to steam distillation and the distillate is cooled,crystallized and filtered to generate crude tetramethylpyrazine which is refined with water recrystallization and activated carbon to decolor. Ethanol solution with 15% to 20% hydrogen chloride can be added into acetone to prepare hydrochloride salt. Condensed by 2,3-butanedione and 2,3-butanediamine.
References	TH Tsai, CC Liang. International Journal of Pharmaceutics, 216. 1-2 (2001) WU, Zhi-youg, et al. Chinese Journal of Experimental Traditional Medical Formulae 14 (2012): 085. Ozaki, Yukihiro. Chemical and pharmaceutical bulletin 40.4 (1992): 954-956. Kao, Tsung-Kuei, et al. Neurochemistry international 48.3 (2006): 166-176. Zhang, Zhaohui, et al. Life sciences 72.22 (2003): 2465-2472.
Chemical Properties	white crystals or powder
Uses	Usually used in research and treatment of multiple disorders.
Definition	ChEBI: A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).

Tetramethylpyrazine Preparation Products And Raw materials

Raw materials

Sodium nitrite-->2,3-Butanedione-->Acetylacetone-->1,4-DIAMINOBUTANE-->Ethyl nitrite-->2-Methylpyrazine

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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Product Details

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career henan chemical co