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Tetramethylpyrazine

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Company Name: HubeiwidelychemicaltechnologyCo.,Ltd
Tel: 18627774460
Email: faith@widelychemical.com
Products Intro: Product Name:Tetramethylpyrazine
CAS:1124-11-4
Purity:0.99 Package:1kg 25kg 200 kilograms per barrel
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
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Products Intro: Product Name:Tetramethylpyrazine
CAS:1124-11-4
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
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Products Intro: Product Name:tetramethylpyrazine
CAS:1124-11-4
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:1124-11-4
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sale@mainchem.com
Products Intro: Product Name:Tetramethylpyrazine
CAS:1124-11-4

Lastest Price from Tetramethylpyrazine manufacturers

  • Tetramethylpyrazine
  • US $0.00 / KG
  • 2019-10-19
  • CAS:1124-11-4
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 1 ton
Tetramethylpyrazine Basic information
Description Chemical Characteristic Uses Preparation References
Product Name:Tetramethylpyrazine
Synonyms:Tetramethylpyrazine 1124-11-4;2 3 5 6-TETRAMETHYLPYRAZINE 98+%;Ligustrazine(tetramethylprazine);Ligustrazine(tetramethylpyrazine);2,3,5,6-TETRAMETHYLPYRAZINE WITH GC;2,3,5,6-TETRAMETHYL PYRAZINE, NATURAL;2,3,5,6-TETRAMETHYLPYRAZINE, SYNTHETIC;2,3,5,6-Tetramethylpyrazine,Ligustrazine
CAS:1124-11-4
MF:C8H12N2
MW:136.19
EINECS:214-391-2
Product Categories:Pyrazine;Heterocyclic Compounds;Pyrazines;Mono- & Polyalkylpyrazines;pyrazine Flavor;Alphabetical Listings;Flavors and Fragrances;Q-Z;Certified Natural ProductsFlavors and Fragrances;Building Blocks;Heterocyclic Building Blocks;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File:1124-11-4.mol
Tetramethylpyrazine Structure
Tetramethylpyrazine Chemical Properties
Melting point 77-80 °C(lit.)
Boiling point 190 °C(lit.)
density 1.08
refractive index 1.5880 (estimate)
FEMA 3237 | 2,3,5,6-TETRAMETHYLPYRAZINE
Fp 128-130°C/200mm
storage temp. Store below +30°C.
solubility 4g/l
form neat
pka3.20±0.10(Predicted)
Water Solubility Soluble in water (4 g/L at 20°C).
JECFA Number780
BRN 113100
Stability:Stable. Incompatible with strong acids, strong oxidizing agents.
InChIKeyFINHMKGKINIASC-UHFFFAOYSA-N
CAS DataBase Reference1124-11-4(CAS DataBase Reference)
NIST Chemistry ReferencePyrazine, tetramethyl-(1124-11-4)
EPA Substance Registry SystemPyrazine, tetramethyl-(1124-11-4)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-37/38-41-36/37/38
Safety Statements 26-39-24/25-37/39-36
WGK Germany 3
RTECS UQ3905000
TSCA Yes
HS Code 29339990
MSDS Information
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Tetramethylpyrazine English
ACROS English
SigmaAldrich English
ALFA English
Tetramethylpyrazine Usage And Synthesis
DescriptionTetramethylpyrazine (TMP) is a kind of alkaloids identified in Ligusticum wallichii FRANCH. It has various kinds of medical applications. It has long been used in China for the treatment of cardiovascular problems. It also has antiinflammatory and analgesic effect. It can be used for the treatment of diabetic peripheral neuropathy. Through effectively penetrating across the blood-brain barrier, it can exert its neuroprotection function which is useful for the treatment of ischemic brain injury. Moreover, it can eliminate superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.
Chemical CharacteristicWhite crystal or powder. With aroma of beef and heated lard and fermented soybean flavor. It smells chocolate flavor when diluted to 20mg/kg. Boiling point is 190℃. Melting point is between 84 and 86℃. Soluble in ethanol, most non-volatile oils and propylene glycol, slightly soluble in water.
Natural products exist in guava, roast beef, cocoa, coffee, shrimp and so on.
Uses
  • Permissible edible flavors, mainly used to prepare meat, cocoa, peanut, nut, coffee, chocolate flavor and so on;
  • For medicine production;
  • Used as flavoring agents, sweeteners for alcoholic beverages, flavor and enriching supplement for cigarettes.
Preparation
  • Butanedione monoxime generated by butanone and ethyl nitrite condensation is reduced and cyclized to produce methylpyrazine. The cyclization reaction product is subjected to steam distillation and the distillate is cooled,crystallized and filtered to generate crude tetramethylpyrazine which is refined with water recrystallization and activated carbon to decolor. Ethanol solution with 15% to 20% hydrogen chloride can be added into acetone to prepare hydrochloride salt.
  • Condensed by 2,3-butanedione and 2,3-butanediamine.
ReferencesTH Tsai, CC Liang. International Journal of Pharmaceutics, 216. 1-2 (2001)
WU, Zhi-youg, et al. Chinese Journal of Experimental Traditional Medical Formulae 14 (2012): 085.
Ozaki, Yukihiro. Chemical and pharmaceutical bulletin 40.4 (1992): 954-956.
Kao, Tsung-Kuei, et al. Neurochemistry international 48.3 (2006): 166-176.
Zhang, Zhaohui, et al. Life sciences 72.22 (2003): 2465-2472.
Chemical Propertieswhite crystals or powder
Chemical Properties2,3,5,6-Tetramethylpyrazine has musty, fermented, coffee odor
OccurrenceReported found in French fried potato, bell pepper, wheat bread, emmental cheese, Swiss cheese, Camembert cheese, Gruyere cheese, boiled and cooked beef, grilled and roasted beef, fried beef, cooked lamb and mutton, lamb and mutton liver, grilled and roasted uncured pork, beer, black tea, green tea. Also reported present in cocoa products, coffee, dairy products, oatmeal, galbanum oil, roasted peanuts, soybean, beans, mushroom, trassi, coriander seed, rice bran, trassi, sukiyaki, soy sauce, malt, licorice, dried bonito, wild rice, shrimp, crab, clam, scallop, filberts, rum, sake, wine, whiskey, burley tobacco and soy products.
UsesUsually used in research and treatment of multiple disorders.
DefinitionChEBI: A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).
PreparationFrom2,5-dimethylpyrazine by ring alkylationwithMeLi; also by condensation of 2,3-butanedionewith 2,3-butanediamine.
Aroma threshold valuesDetection: 1 to 10 ppm. Aroma characteristics at 1.0%: slightly musty, nutty, cocoa-like with a vanilla undernote
Taste threshold valuesTaste characteristics at 10 ppm: weak, nutty, musty cocoa and chocolate-like with dry coffee nuances.
Safety ProfilePoison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
Tetramethylpyrazine Preparation Products And Raw materials
Raw materialsSodium nitrite-->2,3-Butanedione-->Acetylacetone-->1,4-DIAMINOBUTANE-->Ethyl nitrite-->2-Methylpyrazine
Tag:Tetramethylpyrazine(1124-11-4) Related Product Information
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