Betamethasone

Price	$1
Package	1KG

Product Details

Product Name: Betamethasone	CAS No.: 378-44-9
Min. Order: 1G	Purity: 98%
Supply Ability: 100KG	Release date: 2019/07/06

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Betamethasone Basic information

hormone drugs Chemical Properties Uses production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent

Product Name:	Betamethasone
Synonyms:	17,21-trihydr;betamethasone standard;(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;Betamethasone Base & Salts;Betamethasone,9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone;Betamethasone (200 mg);BetaMethasone (Celestone);BetaMethasone SolutioM
CAS:	378-44-9
MF:	C22H29FO5
MW:	392.46
EINECS:	206-825-4
Product Categories:	Steroid and Hormone;Pharmaceutical intermediate;CELESTONE;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	378-44-9.mol

Betamethasone Chemical Properties

Melting point	235-237°C
alpha	D +108° (acetone)
density	1.1283 (estimate)
refractive index	118 ° (C=1, Dioxane)
storage temp.	0-6°C
Merck	14,1180
CAS DataBase Reference	378-44-9(CAS DataBase Reference)
NIST Chemistry Reference	Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9)

Safety Information

Hazard Codes	Xi,Xn,T
Risk Statements	40-48/20/21-61
Safety Statements	22-36-45-53
RTECS	TU4000000
HS Code	29379000
Hazardous Substances Data	378-44-9(Hazardous Substances Data)

MSDS Information

Betamethasone Usage And Synthesis

hormone drugs	Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone . Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension. Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections. The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on. The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties	White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 ℃, slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless.
Uses	Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects.
production method	According to U.S. Patent No. 3,164,618, betamethasone acetate is dealt with hydrochloric acid in methanol-chloroform-water mixture , it can be converted to betamethasone.
Category	Toxic substances
Toxicity grading	Middle toxic
Acute toxicity	Oral-mouse LD50:> 4500 mg/kg
Flammability and hazard characteristics	Combustible;Its combustion produces toxic fumes of fluoride.
Storage Characteristics	Ventilated, low-temperature ,dry storeroom.
Extinguishing agent	Dry powder , foam, sand, carbon dioxide, water spray.
Chemical Properties	White to Off-White Solid
Uses	glucocorticoid, antiinflammatory
Uses	Betamethasone is a glucocorticoid used as an anti-inflammatory agent.
Uses	anti-inflammatory, immunosuppressive

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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Product Details

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career henan chemical co