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Postion:Product Catalog >API>Antibiotics>Lincosamides Drugs>Lincomycin hydrochloride

Lincomycin hydrochloride

US $1.00 / 1KG

Min. Order: 1G
Purity: 98%
Cas No.: 859-18-7
Supply Ability: 100KG
  • 1KG

Overview

Product Name: Lincomycin hydrochloride
CAS No.: 859-18-7
EC-No.:
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2019/07/06
Product Advantage

AD68

Lincomycin hydrochloride Basic information
Antibiotic medicines Clinical application
Product Name: Lincomycin hydrochloride
Synonyms: METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;LINCOMYCIN HCL;LINCOMYCIN HYDROCHLORIDE;LINCOCIN HYDROCHLORIDE;ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;U-10149A;N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE;lincomycin standard solution
CAS: 859-18-7
MF: C18H35ClN2O6S
MW: 443
EINECS: 212-726-7
Product Categories: Antibiotic Explorer;Peptide Synthesis/Antibiotics;Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Lincocin;antibiotic;API
Mol File: 859-18-7.mol
Lincomycin hydrochloride Structure
 
Lincomycin hydrochloride Chemical Properties
Melting point  156-158C
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, colorless
color  white to white with yellow cast
Water Solubility  Soluble in water.
InChIKey POUMFISTNHIPTI-BOMBIWCESA-N
 
Safety Information
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  2
RTECS  RH6315000
10
HS Code  29419000
Lincomycin hydrochloride Usage And Synthesis
Antibiotic medicines Lincomycin hydrochloride appears as a white crystalline powder at room temperature with slight odor or special smell and bitter taste. It is soluble in water and methanol. Feed often applied its hydrochloride salt form. The drug is the product during the growth of the population of the Streptomyces genus (Streptomyces lincolnensis), as a kind of lincosamides alkaline antibiotics. Through interaction with the 50S ribosomal subunit of the sensitive bacteria, it prevents the peptide chain elongation, thereby inhibiting protein synthesis of the bacterial cell with antimicrobial effect. However, at high concentrations, it also has bactericidal effect on the highly sensitive bacteria. Its antibacterial spectrum is the same as lincomycin but with a stronger antibacterial activity and can be subject to oral absorption quickly and completely (about 90%) with meal having little effect on the absorption. Lincomycin hydrochloride mainly has strong antibacterial effect against Gram-positive bacteria, and some anaerobic bacteria as well as Mycoplasma with its antibacterial spectrum narrower than erythromycin. Staphylococcus aureus, Streptococcus pneumoniae and Mycoplasma pneumonia Mycoplasma hyopneumoniae, and Mycoplasma gallisepticum are sensitive to the chemicals, but enterococci is generally resistant to the chemicals; anaerobic bacteria such as Bacteroides spp., Clostridium tetani, Clostridium difficile, Clostridium perfringens and Peptococcus are also sensitive to the chemicals. It is mainly used for the treatment of infections caused by Gram-positive bacteria in particular the various penicillin-resistant Gram-positive bacteria , the poultry chronic respiratory disease caused by Mycoplasma, swine enzootic pneumonia, anaerobic infections such as chicken necrotizing enterocolitis. It can also be used for the treatment of treponema dysentery, toxoplasmosis and actinomycosis of dogs and cats. 
Lincomycin hydrochloride has therapeutic effect when being used for the treatment of Sepsis, female genital tract, endometritis, non-gonococcal tubo-ovarian abscess, pelvic cellulitis; postoperative vaginal annex infections, peritonitis, abscesses, pneumonia, lung abscess, skin and soft tissue infections caused by most Gram-negative bacteria and some anaerobic bacteria. It can also be used for the surgical adjuvant treatment of Sepsis caused by streptococci and staphylococci, bone and joint infections, chronic bone and joint infections as well as the acute hematogenous osteomyelitis of Staphylococcus aureus. But this product can’t penetrate into cerebrospinal fluid and therefore not suitable for the treatment of meningitis. Topical administration can be applied for the treatment of Gram-positive bacteria purulent infection.
Clinical application 1. Oral formulations is suitable for treating respiratory infections, abdominal infection, female reproductive tract infections, pelvic infections, skin and soft tissue infections caused by sensitive Staphylococcus aureus and Streptococcus pneumoniae. 
2. In addition to the treatment of the above infections, injected formulations are suitable for treatment of severe infections caused by streptococcus, pneumococcus and staphylococcus such as the surgical adjuvant therapy of septicemia, bone and joint infections, chronic bone and joint infections and Staphylococcus-induced acute hematogenous osteomyelitis. 
3. Lincomycin hydrochloride may also be used for the treatment of infectious diseases in patients allergic to penicillin or not suitable for administration of penicillin-type drugs. 
Tablets: Each tablet 0.25g, 0.5g; Injection: each 0.2g, 0.6g.
This information is edited by Xiongfeng Dai from Chemicalbook.
Chemical Properties Crystalline
Uses An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
Uses Antibacterial;Ribosomal protein synthesis inhibitor
Uses Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
 
 

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