Ramipril
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Ramipril | CAS No.: 87333-19-5 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| Ramipril Basic information |
| Description References |
| Product Name: | Ramipril |
| Synonyms: | (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid;RaMipril(Altace);(2S,3aS,6aS)-;RaMipril API;Ranipril;PRAMACE;RAMIPRIL;RAMACE |
| CAS: | 87333-19-5 |
| MF: | C23H32N2O5 |
| MW: | 416.51 |
| EINECS: | 1312995-182-4 |
| Product Categories: | API;Cardiovascular & Blood System Agents;Active Pharmaceutical Ingredients;Ramipril;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Angiotensin |
| Mol File: | 87333-19-5.mol |
 |
|
| Ramipril Chemical Properties |
| Melting point | 106-108°C |
| alpha | D24 +33.2° (c = 1 in 0.1N ethanolic HCl) |
| storage temp. | 2-8°C |
| solubility | DMSO: ~18mg/mL |
| color | white |
| CAS DataBase Reference | 87333-19-5(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26-37/39 |
| RTECS | GY5879600 |
| Toxicity | LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer) |
| Ramipril Usage And Synthesis |
| Description | Ramipril (brand name: Altace) is a kind of prodrug which is capable of inhibiting the angiotensin-converting enzyme (ACE) which converting angiotensin I to angiotensin II. It is metabolized to ramiprilat in the liver which exerts the effect of ACE inhibition. It is used for the treatment of hypertension, congestive heart failure and nephropathy. It can also be used for the prevention of heart attack, stroke and cardiovascular death. It can also be used for the treatment of kidney damage due to diabetes with protein-containing urine. Ramiprilat, is the competitive inhibitor of ATI for binding to ACE, further inhibiting the enzymatic proteolysis of ATI to ATII, alleviating the effect of ATII on blood pressure. |
| References | https://en.wikipedia.org/wiki/Ramipril https://www.drugbank.ca/drugs/DB00178 |
| Chemical Properties | White Solid |
| Uses | cardiotonic |
| Uses | An inhibitor of the angiotensin- coverting enzyme (ACE) |
| Uses | An antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite |
| Definition | ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. |
| Uses | Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical] |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $32.00/1KG |
VIP1Y
|
Henan Fengda Chemical Co., Ltd
|
2024-04-15 | |
| $0.00/1kg |
VIP1Y
|
Hangzhou ICH Biofarm Co., Ltd
|
2023-06-27 | |
| $0.00/1KG |
VIP2Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-29 | |
| $10.00/1Kg/Bag |
Hebei Zhanyao Biotechnology Co. Ltd
|
2021-11-19 | ||
| $15.00/1KG |
VIP4Y
|
Hebei Lingding Biotechnology Co., Ltd.
|
2021-09-07 | |
| $1.90/1KG |
VIP3Y
|
Hebei Guanlang Biotechnology Co,.LTD
|
2021-08-11 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-08-11 | ||
| $0.00/1KG |
VIP3Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-07-03 | |
| $0.00/1KG |
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
|
2020-10-30 | ||
| $10.00/1KG |
Hubei XinRunde Chemical Co., Ltd.
|
2018-03-29 |
China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
杨俊青
15093356674
sales@coreychem.com
15093356674
sales@coreychem.com