Methylparaben

Price	$1
Package	1KG

Product Details

Product Name: Methylparaben	CAS No.: 99-76-3
Min. Order: 1G	Purity: 98%
Supply Ability: 100KG	Release date: 2019/07/06

AD68

Product Name:	Methylparaben
Synonyms:	NIPAGIN;NIPAGIN PLAIN;P-HYDROXYBENZOIC ACID METHYL ESTER;RARECHEM AL BF 0098;4-hydroxy-benzoicacimethylester;Abiol;Aseptoform;Benzoic acid, p-hydroxy-, methyl ester
CAS:	99-76-3
MF:	C8H8O3
MW:	152.15
EINECS:	202-785-7
Product Categories:	Aromatic Esters;Antioxidant;Biochemistry;Color Former & Related Compounds;Developer;Functional Materials;Aromatics;API;Other APIs;Cosmetics
Mol File:	99-76-3.mol

Methylparaben Chemical Properties

Melting point	125-128 °C(lit.)
Boiling point	298.6 °C
density	1,46g/cm
FEMA	2710 \| METHYL P-HYDROXYBENZOATE
refractive index	1.4447 (estimate)
Fp	280°C
storage temp.	0-6°C
solubility	ethanol: soluble0.1M, clear, colorless
form	Crystalline Powder
color	White to almost white
Water Solubility	Slightly soluble in water.
FreezingPoint	131℃
Merck	14,6107
BRN	509801
Stability:	Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey	LXCFILQKKLGQFO-UHFFFAOYSA-N
CAS DataBase Reference	99-76-3(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
EPA Substance Registry System	Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22-36
Safety Statements	26-36-24/25-39
RIDADR	UN 2769
WGK Germany	1
RTECS	DH2450000
TSCA	Yes
HS Code	29182930
Hazardous Substances Data	99-76-3(Hazardous Substances Data)

Methylparaben Usage And Synthesis

Content analysis	Method one: determinate according to the content analysis method in "butyl p-hydroxybenzoate (07002)". Per mL 1 mol/L sodium hydroxide is equivalent to the product (C8H8O3) 152.2mg. Method two: Take 0.1 g (accurate to 1 mg) of the sample previously dried on silica gel for 5 h and move into a 300 ml flask with a glass plug. Plus l mol/L sodium hydroxide 10ml, heated in the water bath for 15min. After cooling, add 0.1mol/L potassium bromate 0.00ml, potassium bromide 5.0g and l mol/L hydrochloric acid 30ml. Put 15min in the dark room after sealing. Add potassium iodide 1 g, shake the flask vigorously, with 0.1mol/L sodium thiosulfate titration, with starch test solution (TS-235) as an indicator. Per ml 0.1mol/L potassium bromate is equivalent to the product (C8H8O3) 25.36mg.
Toxicity	ADI 0～10mg/kg(FAO/WHO,2001). GRAS(FDA,§184．1490，2000). LD503000mg/kg(Dog, mouth)
Utilization limitation	FAO/WHO (1984): Jam, jelly, 1000mg/kg (single or with benzoate, sorbic acid and potassium sorbate). EEC(1990,mg/kg): For use in pigment solutions, flavor syrups, coffee extracts, frozen drinks, fruit, glucose and soft drinks, pickled fish, salad, sauce, snack food, concentrated soup and so on, limited to GMP; Beer 70; Snack cereals and soup concentrate 175, the same as "07018 p-hydroxybenzoate". HACSG is listed as a restricted list. FDA,§184.1490(2000):0.1%.
Chemical properties	White needle crystal; Slightly soluble in water, easily soluble in ethanol, ether, acetone and other organic solvents.
Application	Antioxidants. Antimicrobial agents for medicine and organic synthesis. Anti-mildew in food, cosmetics and pharmaceutical industries. As a preservative antiseptic agents in the pharmaceutical industry, also for organic synthesis and food, spices, film and other preservative additives. Similar products produced by similar production methods, like ethyl p-hydroxybenzoate (paraben B) and propyl p-hydroxybenzoate (Nepalese c), are also disinfectant preservatives.The products are irritating to the skin.
Preparation	The drug is esterified with p-hydroxybenzoic acid and methanol. The p-hydroxybenzoic acid was added to excess methanol to dissolve, stirring and adding concentrated sulfuric acid slowly. After heating and refluxing 10h, pour into the water to precipitate crystallization, then washed with water, sodium carbonate solution and water, finally obtain the crude product. Recrystallize from water or 25% ethanol to obtain finished product. The yield was 85%. Raw material consumption (kg/t): p-hydroxybenzoic acid 1200, methanol 1000.
Category	Toxic Chemicals
Toxic grading	Moderate toxicity
Acute toxicity	Abdomen-mouse LD50: 960 mg/kg
Flammability hazard characteristics	Combustible, excretes spicy smoke from fireground
Storage	Ventilated , low temperature and dry warehouse.
Extinguishing agent	Water, carbon dioxide, dry powder, sand.
Chemical Properties	white crystalline powder
Uses	It is used as preservative in foods, beverages and cosmetics.
Definition	ChEBI: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blu berries.
Uses	As preservative in foods, beverages and cosmetics.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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