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Postion:Product Catalog >API>Antiallergic drugs>Antihistamines>Promethazine hydrochloride

Promethazine hydrochloride

US $1.00 / 1KG

Min. Order: 1G
Purity: 98%
Cas No.: 58-33-3
Supply Ability: 100KG
  • 1KG

Overview

Product Name: Promethazine hydrochloride
CAS No.: 58-33-3
EC-No.:
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2019/07/06
Product Advantage

AD68

Promethazine hydrochloride Basic information
Product Name: Promethazine hydrochloride
Synonyms: 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride
CAS: 58-33-3
MF: C17H21ClN2S
MW: 320.88
EINECS: 200-375-2
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors
Mol File: 58-33-3.mol
Promethazine hydrochloride Structure
 
Promethazine hydrochloride Chemical Properties
Melting point  230-232°C
Fp  9℃
storage temp.  Refrigerator
λmax 297nm(H2O)(lit.)
Merck  14,7786
InChIKey XXPDBLUZJRXNNZ-UHFFFAOYSA-N
CAS DataBase Reference 58-33-3(CAS DataBase Reference)
EPA Substance Registry System 10H-Phenothiazine- 10-ethanamine, N,N,.alpha.-trimethyl-, monohydrochloride(58-33-3)
 
Safety Information
Hazard Codes  Xn,N
Risk Statements  22-36/37/38-51/53-43-20/22
Safety Statements  26-36-61-60-36/37/39-28-22
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  SO8225000
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 i.v. in mice: 55.0 mg/kg (Rajsner)
Promethazine hydrochloride Usage And Synthesis
Chemical Properties White Solid
Uses Antihistaminic, antiemetic, CNS depressant
Uses stool softener
Uses For the treatment of allergic disorders, and nausea/vomiting.
Definition ChEBI: The hydrochloride salt of promethazine.
Uses Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.
General Description Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0.
Air & Water Reactions Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble.
Reactivity Profile Promethazine hydrochloride is sensitive to light. In aqueous solution, Promethazine hydrochloride is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation .
Fire Hazard Flash point data for Promethazine hydrochloride are not available; however, Promethazine hydrochloride is probably combustible.
 

Country:China

Business model: Trader,Manufacturer

CB index: 58

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