![5-Aminolevulinic acid hydrochloride](/ProductImageEN/2022-10/Large/1381db60-d4c0-44e3-be4f-4ac71991a1d1.jpg)
5-Aminolevulinic acid hydrochloride
Price | $10 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | Ex 20 tons |
Update Time: | 2022-10-11 |
Product Details
Product Name: 5-Aminolevulinic acid hydrochloride | CAS No.: 5451-09-2 |
EC-No.: 226-679-5 | Min. Order: 1kg |
Purity: 99% | Supply Ability: Ex 20 tons |
Release date: 2022/10/11 |
Use of 5-Aminolevulinic acid hydrochloride
5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2].
Name | 5-Aminolevulinic Acid Hydrochloride |
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Synonym | More Synonyms |
Description | 5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2]. |
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Related Catalog | Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Metabolic Disease Natural Products >> Others |
Solvent | In Vitro: DMSO : ≥ 150 mg/mL (895.04 mM) H2O : ≥ 50 mg/mL (298.35 mM) * "≥" means soluble, but saturation unknown. |
Solubility | 1 mM5.9669 mL29.8347 mL59.6694 mL5 mM1.1934 mL5.9669 mL11.9339 mL10 mM0.5967 mL2.9835 mL5.9669 mL |
Storage | 4°C, protect from light |
Shipping | Room temperature in continental US; may vary elsewhere |
SMILES | O=C(O)CCC(CN)=O.[H]Cl |
References | [1]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401. [2]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885. |
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