Welcome to chemicalbook!
400-158-6606

Get started now

or
My Account
Buyers
Inquiry management
Suppliers
Quotation management
Request for quotation
My ChemicalBook
My ChemicalBook
Postion:Product Catalog >Ponatinib Hydrochloride

Ponatinib Hydrochloride

US $1.00-2.00 / KG

Min. Order: 1KG
Purity: 95.0-99.8%
Cas No.: 1114544-31-8
Supply Ability: 1KG;5KG 10KG; 100KG
  • 1KG
  • 1KG

Overview

Product Name: Ponatinib Hydrochloride
CAS No.: 1114544-31-8
EC-No.:
Min. Order: 1KG
Purity: 95.0-99.8%
Supply Ability: 1KG;5KG 10KG; 100KG
Release date: 2019/09/03
Product number: Crystal-liu
Product Advantage
Product Name:
Ponatinib Hydrochloride
Synonyms:
AP24534 Mono-hydrochloride;Ponatinib Mono-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride;Ponatinib hydrochloride;Ponatinib-HCl;AP24534-HCl;1114544-31-8
CAS:
1114544-31-8
MF:
C29H28ClF3N6O
MW:
569.02
EINECS:
1592732-453-0
Product Categories:
 
Mol File:
1114544-31-8.mol
Ponatinib Hydrochloride Structure
 
Ponatinib Hydrochloride Chemical Properties
 
Safety Information
MSDS Information
 
 
Ponatinib Hydrochloride Usage And Synthesis
Description
In December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr–Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr– AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.
Originator
Ariad (United States)
Brand name
Iclusig

Country:China

Business model: Trader,Manufacturer

CB index: 58

Audit supplier

  • Telephone: +86-371-86658258
  • Fax:
  • Mobile: 13203830695
  • Address: No 70, Dianchang Road, Zhengzhou City, China

You may like

1-Methylcyclohexanol

1-Methylcyclohexanol

CAS:590-67-0

USD $ 240.00 / 1KG

UV 312

UV 312

CAS:23949-66-8

USD $ 750.00 / 25KG

Nitroethylene

Nitroethylene

CAS:3638-64-0

USD $ 2.00/ G-10.00 / KG

	4-(4-Methoxyphenyl)butyric acid

4-(4-Methoxyphenyl)butyric acid

CAS:4521-28-2

USD $ 2.00/ KG-10.00 / KG

	4-(P-TOLYL)BUTYRIC ACID

4-(P-TOLYL)BUTYRIC ACID

CAS:4521-22-6

USD $ 2.00/ KG-10.00 / KG