M344
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 200kg |
| Update Time: | 2019-12-26 |
Product Details
| Product Name: M344 | CAS No.: 51456-60-7 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 200kg | Release date: 2019/12/26 |
Mary
▼
▲
Product Name:
M344
Synonyms:
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide;MS 344;4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide;M 344 (enzyme inhibitor);MS 344, D237;Histone Deacetylase Inhibitor III(M344);M344
CAS:
251456-60-7
MF:
C16H25N3O3
MW:
307.39
EINECS:
Product Categories:
Apoptosis Inducers;Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor
Mol File:
251456-60-7.mol
▼
▲
M344 Chemical Properties
▼
▲
Melting point
161℃
storage temp.
2-8°C
solubility
DMSO: soluble10mg/mL, clear
form
White solid
color
white to beige
Sensitive
Light Sensitive
▼
▲
Safety Information
▼
▲
WGK Germany
3
▼
▲
MSDS Information
▼
▲
M344 Usage And Synthesis
▼
▲
Uses
Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.
Uses
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).
Biological Activity
Histone deacetylase inhibitor (IC 50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
▼
▲
M344 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time |
|---|
China- Since: 2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
INQUIRY