Product Details
| Product Name: Hydroxychloroquine sulfate | CAS No.: 747-36-4 |
| Min. Order: 10g | Purity: 99.8% |
| Supply Ability: 10tons | Release date: 2021/03/17 |
Name Hydroxychloroquine sulfate
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Description
Hydroxychloroquine sulfate is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling.
Related Catalog
Signaling Pathways >> Anti-infection >> Parasite
Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Infection
Research Areas >> Cancer
Target
Antimalarial[1], TLR7/9[2]
In Vitro
Hydroxychloroquine sulfate is a synthetic antimalarial drug derived from 4-aminoquinoline; it has been used for several decades for the treatment of some rheumatic diseases such as rheumatoid arthritis (RA)[1]. Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands[2].
In Vivo
Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling[2].
Kinase Assay
Five microliters of a solution of 2% L-α-phosphatidylcholine in dodecane is deposited per well on membranes of a 96-well plate. AT791 (10 µM), E6446 (10 µM), Hydroxychloroquine sulfate (40 µM), or chloroquine (40 µM) are added to one of the two compartments in pH 5.5 buffer (50 mM NaAce, 15 mM NaCl) or pH 7.4 buffer (50 mM KPO4, 150 mM NaCl), and the plate is incubated at 37°C. The next day, compound concentrations in both chambers are quantitated. In one variation of this experiment, 5 µM AT791 or E6446 is added to both chambers, one of which contains pH 5.5 buffer and the other pH 7.4 buffer. The redistribution of compound between the two chambers is monitored for 8 hours[2].
Animal Admin
MRL/lpr mice are dosed orally five times a week with 20 or 60 mg/kg E6446 or 60 mg/kg Hydroxychloroquine sulfate beginning at 5 weeks of age. Cytoxan is administered at 50 mg/kg i.p. every 10 days. A serum sample is taken immediately before the beginning of treatment to monitor changes in autoreactive antibodies. Subsequently, serum samples are collected approximately monthly and analyzed for anti-dsDNA by ELISA after 1:500 dilution. Body weights and urine samples are taken at the same interval, and proteinuria is assessed. Anti-nuclear antibodies (ANA) are assessed using commercially available HEp2 slide kits, with serum diluted to 1:100 in kit buffer. ANA scores are read blinded[2].
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Boiling Point
516.7ºC at 760 mmHg
Melting Point
240 °C
Molecular Formula
C18H28ClN3O5S
Molecular Weight
433.950
Flash Point
266.3ºC
Exact Mass
433.143829
PSA
131.37000
LogP
4.28400
Company Profile Introduction
Welcome to hebei Shuoxi biotechnology co., LTD. Shuoxi is a fast developing pharmaceutical intermediates enterprise located in shijiazhuang, capital of hebei province.
Shuoxi analysis research and development center also provides custom synthesis service.
Hebei Shuoxi biotechnology co., LTD can provide customized synthetic chemicals in different quantities in laboratories, factories and industrial scale.
We have more than 10 years experience in this field.
We can offer competitive price for every customer and guarantee the quality of our products.
3. We pay attention to the needs of each customer and build a good relationship with them.
4. We have long-term business relations with Canada, Mexico, Brazil, UK, Russia, Germany, USA, India, South Africa, Malta, Egypt, Armenia, Australia, Philippines, Belgium, Netherlands, Denmark and other countries.
If you have any other questions for me. Please feel free to contact me.
We only produce and sell products that are legal in China. All products are sold only to laboratory research.
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China- Since: 2016-11-14
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