Tulathromycin

Tulathromycin is a concentration-dependent, bacteriostatic, macrolide antibiotic. Tulathromycin is active against Gram-negative aerobes and has improved efficacy against Gram-negative aerobes compared to other macrolide antibiotics. Tulathromycin is also efficacious against Mycoplasma spp. and anaerobes such as Fusobacterium spp. Distribution is wide throughout the body, and tulathromycin has a tendency to accumulate and persist in the lungs. Excretion is primarily as unchanged drug in feces and urine.

Current Uses within OSU-VMC

• Treatment or control of bovine respiratory disease associated with Mannheimia spp., Pasteurella spp., Histophilus spp., or Mycoplasma spp.
• Treatment or control of swine respiratory disease associated with Actinobacillus spp., Pasteurella spp., Bordetella bronchiseptica, Haemophilus spp., or Mycoplasma spp.
• Treatment of bovine interdigital necrobacillosis (foot rot).
• Treatment of infectious bovine keratoconjunctivitis (pinkeye).

Contraindicated Uses

• Not approved for use in lactating dairy cattle (>20 months of age)

Illegal Uses

• Although not illegal, since this product is not approved for use in lactating dairy cattle, a zero drug tolerance is established in any tissues (meat or milk) from dairy cattle > 20 months of age.