Acetylsalicylic acid NEW

Aspirin is a white crystal or crystalline powder, odorless or slightly smelly of acetic acid, slightly soluble in water, easily soluble in ethanol,  and its aqueous solution is acidic. This product is a derivative of salicylic acid. After nearly a hundred years of clinical application, it has been proved to be effective in relieving mild or moderate pain, such as toothache, headache, neuralgia, muscle pain and dysmenorrhea. It is also used for colds, flu, etc. Antipyretic of febrile diseases, treatment of rheumatic pain, etc.

Product Name:    Acetylsalicylic acid

Synonyms:    O-ACETYLSALICYLIC ACID;O-ACETOXYBENZOIC ACID;2-Acetoxybenzoesre,Aspirin;2-Acetoxybenzoic acid~Aspirin;aspirin usp;o-Acetylsalicylic acid 2-Acetoxybenzoic acid;ASPIRIN (AECTAMINOPHIN);ACETYLSALICYLIC ACID BP2000
CAS:    50-78-2
MF:    C9H8O4
MW:    180.16
EINECS:    200-064-1
Product Categories:    Pharmaceutical;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope;Lipid signaling;Anti-Allergic Agents, Antibiotic;LOPROX;50-78-2
Mol File:    50-78-2.mol


Acetylsalicylic acid, also known as aspirin, is an analgesic-antipyretic medicine made by salicylic acid interacting with acetic anhyd ride. It is a white crystalline powder, odorless, stable in dry air. It will be slowly hydrolyzed to be salicylic acid and acetic acid in moist air, and aqueous solution has acidic reaction. Slightly soluble in water, soluble in ethanol, ethyl eth er, chloro form, sodium hydro xide solution and sodium carbonate solution. Acetylsalicylic acid has antipyretic analgesic, anti-inflammatory and anti-rheumatism effect, that's why it is often used for fever, headache, muscle pain, neuralgia, rheumatic fever, acute rheumatic arthritis, gout, etc.; also it has antiplatelet aggregation effect, and can be used for prevention of arterial thrombosis, atherosclerosis, transient cerebral ischemia and myocardial infarction; in addition, acetylsalicylic acid also can be used in the treatment of biliary tract roundworm disease and athlete's foot.

Aspirin / Acetylsalicylic Acid CAS 50-78-2 of Chemical Properties
Melting point     134-136 °C (lit.)
Boiling point     272.96°C (rough estimate)
density     1.35
refractive index     1.4500 (estimate)
Fp     250 °C
storage temp.     2-8°C
solubility     H2O: 10 mg/mL at 37 °C
form     crystalline
color     white
pka    3.5(at 25ºC)
Water Solubility     3.3 g/L (20 ºC)
Merck     14,851
BRN     779271
Exposure limits    ACGIH: TWA 5 mg/m3
NIOSH: TWA 5 mg/m3
Stability:    Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc.
InChIKey    BSYNRYMUTXBXSQ-UHFFFAOYSA-N
CAS DataBase Reference    50-78-2(CAS DataBase Reference)
NIST Chemistry Reference    Benzoic acid, 2-(acetyloxy)-(50-78-2)
EPA Substance Registry System    Aspirin (50-78-2)

Function and Application of Aspirin / Acetylsalicylic Acid CAS 50-78-2
1. Aspirin / Acetylsalicylic Acid is the earliest, most widely used and most common antipyretic and analgesic anti-rheumatic drug. It has various pharmacological effects such as antipyretic, analgesic, anti-inflammatory, anti-rheumatic and anti-platelet aggregation, etc. It has rapid and definite efficacy, easy to diagnose and deal with overdose, and allergic reactions rarely occur.
2. Aspirin / Acetylsalicylic Acid also prevents platelets from clumping in broken blood vessels and has an anticoagulant effect.
3. Aspirin can treat a wide range of conditions including fever, pain, rheumatic fever and also some inflammatory conditions such as rheumatoid arthritis, pericarditis and Kawasaki disease.

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