Antipyretic analgesics

Antipyretic-analgesics drugs are a class of drugs with antipyretic, analgesic and most also having anti-inflammatory and anti-rheumatic effect. It exerts its antipyretic, analgesic and anti-inflammatory effect primarily by inhibiting the synthesis of prostaglandin in the central nervous system and peripheral tissues. However, for its analgesic effect, it can only be used to clear only weak to moderate pain.

Fever is an intrinsic defense reaction of the body of children with however high temperature fever affecting the body of the children adversely such as causing high-fever seizures with being life-threatening in severe cases. Timely administration of antipyretic-analgesics drugs can reduce the body temperature, alleviate the symptoms and prevent the convulsions and other complications. However, it should be noted that the plummeted temperature and excessive sweating have risks of causing collapse. Therefore, overdose should be avoided. The patients should also drink enough water after taking the drugs. Children of history of febrile convulsions can take it in combination with sedatives such as luminal. In case of fever, early administration of paracetamol tablets can prevent febrile convulsions.

According to the chemical structures, it can be divided into four categories:
1. Aniline; such as phenacetin, acetaminophen and so on.
2. Pyrazolones; such as aminopyrine, dipyrone, phenylbutazone and so on.
3. Salicylic acid; such as aspirin, sodium salicylate.
4. Novel anti-inflammatory analgesics drugs; such as indomethacin, mefenamic acid, ibuprofen and ibuprofen, ketoprofen and so on. This class of drugs has common adverse reactions such as rash, leukopenia, angioedema and anaphylactic shock can occur in small number of patients. Large doses can cause gastrointestinal reactions and liver and kidney dysfunction.

Aspirin has a stimulating effect on the gastrointestinal tract with long-term administration being able to cause gastritis, gastric ulcers and bleeding and inducing bronchial asthma and Reye's syndrome, being manifested as convulsions coma and liver damage. Analgin, in addition to general adverse reactions, occasionally cause severe leukopenia, exfoliative dermatitis and drug fever. Paracetamol class has fewer adverse reactions and is non-irritating to the stomach without causing stomach bleeding except occasional skin rashes and other allergic reactions. However, long-term administration of large doses may have liver and kidney dysfunction. Phenacetin, aminopyrine and other side effects are relative severe, therefore, minimizing the administration of aspirin compound (i.e. APC) class of drugs. Currently there is trend of promoting application of paracetamol and single administration of small amount of water-soluble aspirin.

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Structure Chemical Name CAS MF
Etoricoxib Etoricoxib 202409-33-4 C18H15ClN2O2S
PARECOXIB SODIUM PARECOXIB SODIUM 198470-85-8 C19H17N2NaO4S
Lornoxicam Lornoxicam 70374-39-9 C13H10ClN3O4S2
Iguratimod Iguratimod 123663-49-0 C17H14N2O6S
Pranoprofen Pranoprofen 52549-17-4 C15H13NO3
TETRAHYDROPALMATINE HYDROCHLORIDE TETRAHYDROPALMATINE HYDROCHLORIDE 6024-85-7 C21H26ClNO4
BUCILLAMINE BUCILLAMINE 65002-17-7 C7H13NO3S2
Celecoxib Celecoxib 169590-42-5 C17H14F3N3O2S
Flurbiprofen Flurbiprofen 5104-49-4 C15H13FO2
Paeonol Paeonol 552-41-0 C9H10O3
Parecoxib Parecoxib 198470-84-7 C19H18N2O4S
Lomerizine Lomerizine 101477-55-8 C27H30F2N2O3
Antipyrine Antipyrine 60-80-0 C11H12N2O
Naproxen Naproxen 22204-53-1 C14H14O3
Fentanyl citrate Fentanyl citrate 990-73-8 C28H36N2O8
Rofecoxib Rofecoxib 162011-90-7 C17H14O4S
Ketorolac Ketorolac 74103-06-3 C15H13NO3
Ibuprofen Ibuprofen 15687-27-1 C13H18O2
Phenylbutazone Phenylbutazone 50-33-9 C19H20N2O2
Neochlorogenic acid Neochlorogenic acid 906-33-2 C16H18O9
Tetrahydropalmatine Tetrahydropalmatine 10097-84-4 C21H25NO4
Allopurinol Allopurinol 315-30-0 C5H4N4O
Sodium salicylate Sodium salicylate 54-21-7 C7H5NaO3
Piroxicam Piroxicam 36322-90-4 C15H13N3O4S
Eletriptan Eletriptan 143322-58-1 C22H26N2O2S
4-Acetamidophenol 4-Acetamidophenol 103-90-2 C8H9NO2
Aminophenazone Aminophenazone 58-15-1 C13H17N3O
Indometacin Indometacin 53-86-1 C19H16ClNO4
N-Sulfo-glucosamine potassium salt N-Sulfo-glucosamine potassium salt 31284-96-5 C6H12KNO8S
Tenoxicam Tenoxicam 59804-37-4 C13H11N3O4S2
D-Glucosamine hydrochloride D-Glucosamine hydrochloride 66-84-2 C6H14ClNO5
Meloxicam Meloxicam 71125-38-7 C14H13N3O4S2
Chlorogenic acid Chlorogenic acid 327-97-9 C16H18O9
Carbasalate calcium Carbasalate calcium 5749-67-7 C18H14CaO8.CH4N2O
Etodolac Etodolac 41340-25-4 C17H21NO3
Ketoprofen Ketoprofen 22071-15-4 C16H14O3
Niflumic acid Niflumic acid 4394-00-7 C13H9F3N2O2
Zolmitriptan Zolmitriptan 139264-17-8 C16H21N3O2
URICASE URICASE 9002-12-4 C18H26N5O14P
(+)-Bicuculline (+)-Bicuculline 485-49-4 C20H17NO6
Zaltoprofen Zaltoprofen 89482-00-8 C17H14O3S
Febuxostat Febuxostat 144060-53-7 C16H16N2O3S
Salicylamide Salicylamide 65-45-2 C7H7NO2
Acetylsalicylic acid Acetylsalicylic acid 50-78-2 C9H8O4
Dulcitol Dulcitol 608-66-2 C6H14O6
1-(2,6-Dichlorophenyl)-2-indolinone 1-(2,6-Dichlorophenyl)-2-indolinone 15307-86-5 C14H9Cl2NO
florfenicol(Water soluble) florfenicol(Water soluble)
Mefenamic acid Mefenamic acid 61-68-7 C15H15NO2
Diclofenac sodium Diclofenac sodium 15307-79-6 C14H10Cl2NNaO2
Flufenamic acid Flufenamic acid 530-78-9 C14H10F3NO2
(S)-(+)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (S)-(+)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 51543-39-6 C15H13FO2
Sodium butazolidine Sodium butazolidine 129-18-0 C19H19N2NaO2
Probenecid Probenecid 57-66-9 C13H19NO4S
D-Tetrandrine D-Tetrandrine 518-34-3 C38H42N2O6
Nimesulide Nimesulide 51803-78-2 C13H12N2O5S
Benzidamine hydrochloride Benzidamine hydrochloride 132-69-4 C19H23N3O.ClH
Aceclofenac Aceclofenac 89796-99-6 C16H13Cl2NO4
Carprofen Carprofen 53716-49-7 C15H12ClNO2
Droxicam Droxicam 90101-16-9 C16H11N3O5S
2-BENZOYLACETANILIDE 2-BENZOYLACETANILIDE 959-66-0 C15H13NO2
MEPERIDINE MEPERIDINE 57-42-1 C15H21NO2
Lobenzarit Lobenzarit 63329-53-3 C14H10ClNO4
Sasapyrine Sasapyrine 552-94-3 C14H10O5
Oxaprozin Oxaprozin 21256-18-8 C18H15NO3
Leflunomide Leflunomide 75706-12-6 C12H9F3N2O2
Fenbufen Fenbufen 36330-85-5 C16H14O3
Nabumetone Nabumetone 42924-53-8 C15H16O2
Methocarbamol Methocarbamol 532-03-6 C11H15NO5
Sulindac Sulindac 38194-50-2 C20H17FO3S
Sumatriptan Sumatriptan 103628-46-2 C14H21N3O2S
ROTUNDINUM ROTUNDINUM 2934-97-6 C21H25NO4
2-Hydroxybenzylamine 2-Hydroxybenzylamine 932-30-9 C7H9NO
Bendazac Bendazac 20187-55-7 C16H14N2O3
Pizotifen Pizotifen 15574-96-6 C19H21NS
BENZBROMARONE BENZBROMARONE 3562-84-3 C17H12Br2O3
Meptazinol hydrochloride Meptazinol hydrochloride 59263-76-2 C15H24ClNO
Tiaprofenic acid Tiaprofenic acid 33005-95-7 C14H12O3S
Loxoprofen sodium Loxoprofen sodium 80382-23-6 C15H17NaO3
Propyphenazone Propyphenazone 479-92-5 C14H18N2O
Nefopam hydrochloride Nefopam hydrochloride 23327-57-3 C17H20ClNO
DL-Lysine acetylsalicylate DL-Lysine acetylsalicylate 62952-06-1 C15H22N2O6
Flunixin meglumin Flunixin meglumin 42461-84-7 C21H28F3N3O7
2-Ethoxybenzamide 2-Ethoxybenzamide 938-73-8 C9H11NO2
OXYPHENBUTAZONE HYDRATE OXYPHENBUTAZONE HYDRATE 7081-38-1 C19H22N2O4
Clofenamic acid Clofenamic acid 13278-36-9 C13H10ClNO2
Propacetamol hydrochloride Propacetamol hydrochloride 66532-86-3 C14H21ClN2O3
Butibufen Butibufen 55837-18-8 C14H20O2
MECLOFENAMATE SODIUM MECLOFENAMATE SODIUM 6385-02-0 C14H10Cl2NO2.Na
Dipyrone Dipyrone 68-89-3 C13H16N3NaO4S
Naproxen sodium Naproxen sodium 26159-34-2 C14H13O3.Na
(R)-2-Flurbiprofen (R)-2-Flurbiprofen 51543-40-9 C15H13FO2
Loxoprofen Loxoprofen 68767-14-6 C15H18O3
CHELIDONINE CHELIDONINE 476-32-4 C20H19NO5
CINCHOPHEN CINCHOPHEN 132-60-5 C16H11NO2
FLURBIPROFEN AXETIL FLURBIPROFEN AXETIL 91503-79-6 C19H19FO4
1-PHENYLSEMICARBAZIDE 1-PHENYLSEMICARBAZIDE 103-03-7 C7H9N3O
Florfenicol Florfenicol 73231-34-2 C12H14Cl2FNO4S
Bulleyaconitine A Bulleyaconitine A 107668-79-1 C35H49NO9
Diclofenac potassium Diclofenac potassium 15307-81-0 C14H10Cl2KNO2
Diflunisal Diflunisal 22494-42-4 C13H8F2O3
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