Product Details
| Product Name: Afoxolaner | CAS No.: 1093861-60-9 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 10000 | Release date: 2025/12/03 |

Afoxolaner (CAS 1093861-60-9) – Chemical Properties & Overview
Property Description
IUPAC Name:4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-1-naphthalenecarboxamide
Molecular Formula:C₂₆H₁₄ClF₆N₃O₃
Molecular Weight:553.85 g/mol
CAS Number:1093861-60-9
Appearance:White to pale yellow crystalline powder
Solubility:Insoluble in water; soluble in DMSO, ethanol
Melting Point:150–155°C
Chemical Class:Isoxazoline derivative
Mechanism of Action:GABA/glutamate-gated chloride channel inhibitor (arthropod-specific)
Primary Use:Veterinary ectoparasiticide (fleas & ticks)
Target Animals:Dogs (oral administration)
Commercial Products:NexGard® (Merial/Boehringer Ingelheim)
Regulatory Approvals:FDA (USA), EMA (EU), VICH guidelines
Key Benefits:Monthly oral treatment, rapid killing of parasites, low mammalian toxicity

Afoxolaner (CAS 1093861-60-9) - Quality Control Specification
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | White to pale yellow crystalline powder | Visual inspection |
| Identification | Complies (HPLC/IR vs. reference standard) | HPLC, IR spectroscopy |
| Purity (HPLC) | ≥ 98.0% | Reverse-phase HPLC |
| Water Content (KF) | ≤ 0.5% w/w | Karl Fischer titration |
| Residue on Ignition | ≤ 0.1% | USP <281> |
| Heavy Metals | ≤ 10 ppm (as Pb) | ICP-MS / USP <231> |
| Related Substances | Total impurities ≤ 2.0% Any single impurity ≤ 0.5% | HPLC (area normalization) |
| Particle Size | 90% ≤ 100 µm (customizable) | Laser diffraction (if applicable) |
| Solubility | Insoluble in water; Soluble in DMSO/ethanol | Solubility test |
| Microbial Limits | Total aerobic count ≤ 1000 CFU/g Yeast/mold ≤ 100 CFU/g No pathogens detected | USP <61>, <62> |
| Storage Conditions | 2-8°C (dry, protected from light) | Label requirement |
| Shelf Life | 24 months (unopened, under recommended storage) | Stability studies |

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- Since: 2019-11-21
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