Amitriptyline hydrochloride NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Amitriptyline hydrochloride | CAS No.: 549-18-8 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Amitriptyline hydrochloride |
| Description | Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
| In vitro | Amitriptyline inhibits Forskolin-stimulated cyclic AMP accumulation with EC50 values of 16.2 μM in intact CHO/DOR cells. Amitriptyline causes a concentration-dependent stimulation of ERK1/2 and GSK-3β phosphorylation with EC50 values of 9.0 μM in CHO/DOR cells. Amitriptyline (15 μM) causes a stimulation of ERK1/2 phosphorylation in C6 cells. Amitriptyline (30 μM) inhibits Forskolin-stimulated adenylyl cyclase activity and antagonizes ( )-U50,488 inhibitory effect in rat nucleus accumbens. [5] Amitriptyline binds the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Amitriptyline (< 500 nM) promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline selectively protects T17 cells from apoptosis with EC50 of 50 nM. [6] |
| In vivo | Amitriptyline (15 mg/kg, i.p.) activates TrkA and TrkB receptors and significantly reduces kainic acid-triggered neuronal cell death in mice. [6] Amitriptyline (15 mg/kg and 30 mg/kg, i.p.) dose-dependently decreases the immobility time in the forced swimming test (FST) of mice. Amitriptyline (15 mg/kg, i.p.) shows a significant 24-h rhythm in the immobility time in the forced swimming test (FST) of mice. [7] Amitriptyline (1 mg/kg and 3 mg/kg) significantly increases the total distance travelled of mice in novel cages. Amitriptyline (10 mg/kg p.o., twice daily) considerably attenuates the hypothermic response to 8-OHDPAT and mCPP in mice. Amitriptyline (10 mg/kg p.o., twice daily) significantly reduces serotonin transporter density by approximately 20% in cortex of mice. [8] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (159.31 mM), Sonication is recommended. H2O : 12 mg/mL (38.23 mM), Sonication is recommended. Ethanol : 59 mg/mL (187.98 mM), Sonication is recommended. |
| Keywords | σ1 | Tropomyosin related kinase receptor | Trkreceptor | TrkA/TrkB | Trk receptor | Trk Receptor | SodiumChannel | Sodium Channel | SLC6A4 | Sigmareceptor | Sigma receptor | SERT | SerotoninTransporter | Serotonin Transporter | Serotonin Receptor | psychiatric | pain | Norepinephrine receptor | neurotrophins | neuropathic | neurologic | Na+ channels | Na channels | Muscarinic acetylcholine receptor | mAChR | Inhibitor | inhibit | HistamineReceptor | Histamine Receptor | heterodimerization | diseases | depression | Beta Receptor | Amitriptyline Hydrochloride | Amitriptyline hydrochloride | Amitriptyline | AdrenergicReceptor | Adrenergic Receptor | 5-hydroxytryptamine Receptor | 5-HTT | 5HTReceptor | 5-HT4 | 5-HT2 | 5-HT Receptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Adiphenine hydrochloride | Phenytoin sodium | Alverine citrate | Procaine | Meclizine dihydrochloride | Dapoxetine hydrochloride | Urethane | Famotidine | Valproic Acid | Lidocaine hydrochloride | L-Aspartic aicd sodium | Sodium butanoate |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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